N-Heterocyclic Carbene-Catalyzed Oxidative Amidation of Aldehydes with Amines

被引：48

作者：

Alanthadka, Anitha ^{[1
]}

Maheswari, C. Uma ^{[1
]}

机构：

[1] SASTRA Univ, Sch Chem & Biotechnol, Dept Chem, Organ Synth Grp, Thanjavur 613401, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 06期

关键词：

amides; N-heterocyclic carbenes; organic catalysis; oxidation; oxidative amidation; AEROBIC OXIDATION; AROMATIC-ALDEHYDES; THIAMINE ACTION; AMIDE SYNTHESIS; ALCOHOLS; COMPLEXES; FUNCTIONALIZATION; ESTERIFICATIONS; MECHANISM; CLEAVAGE;

D O I：

10.1002/adsc.201400739

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The N-heterocyclic carbene (NHC)-catalyzed oxidative amidation of aromatic aldehydes with amines in the presence of N-bromosuccinimide (NBS) as an oxidant has been developed for the synthesis of amides. This amidation strategy is tolerant to both the electronic and the steric nature of the aryl aldehydes employed. The present methodology was extended to chiral amino acid derivatives to generate the corresponding amides in good yields and excellent ee values (> 98%).

引用

页码：1199 / 1203

页数：5

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