Systemic IL-15, IFN-γ, and IP-10/CXCL10 signature associated with effective immune response to SARS-CoV-2 in BNT162b2 mRNA vaccine recipients

被引：161

作者：

Bergamaschi, Cristina ^{[1
]}

Terpos, Evangelos ^{[2
]}

Rosati, Margherita ^{[3
]}

Angel, Matthew ^{[4
,5
]}

Bear, Jenifer ^{[1
]}

Stellas, Dimitris ^{[3
]}

Karaliota, Sevasti ^{[3
,6
]}

Apostolakou, Filia ^{[7
]}

Bagratuni, Tina ^{[2
]}

Patseas, Dimitris ^{[2
]}

Gumeni, Sentiljana ^{[8
]}

Trougakos, Ioannis P. ^{[8
]}

Dimopoulos, Meletios A. ^{[2
]}

Felber, Barbara K. ^{[1
]}

Pavlakis, George N. ^{[3
]}

机构：

[1] NCI, Human Retrovirus Pathogenesis Sect, Vaccine Branch, Ctr Canc Res, Frederick, MD 21702 USA

[2] Natl & Kapodistrian Univ Athens, Sch Med, Dept Clin Therapeut, Athens 11528, Greece

[3] NCI, Human Retrovirus Sect, Vaccine Branch, Ctr Canc Res, Frederick, MD 21702 USA

[4] NCI, Vaccine Branch, Ctr Canc Res, Bethesda, MD 20892 USA

[5] Frederick Natl Lab Canc Res, Ctr Canc Res Collaborat Bioinformat Resource, Leidos Biomed Res Inc, Frederick, MD 21702 USA

[6] Frederick Natl Lab Canc Res, Basic Sci Program, Frederick, MD 21702 USA

[7] Aghia Sophia Childrens Hosp, Dept Clin Biochem, Athens 11527, Greece

[8] Natl & Kapodistrian Univ Athens, Fac Biol, Dept Cell Biol & Biophys, Athens 15784, Greece

来源：

CELL REPORTS | 2021年 / 36卷 / 06期

关键词：

YELLOW-FEVER VACCINE; ANTIBODY-RESPONSES; INTERFERON-GAMMA; IN-VIVO; CYTOKINE; CELLS; INFLAMMATION; COVID-19; PROMOTES; BIOLOGY;

D O I：

10.1016/j.celrep.2021.109504

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Early responses to vaccination are important for shaping both humoral and cellular protective immunity. Dissecting innate vaccine signatures may predict immunogenicity to help optimize the efficacy of mRNA and other vaccine strategies. Here, we characterize the cytokine and chemokine responses to the 1st and 2nd dose of the BNT162b2 mRNA (Pfizer/BioNtech) vaccine in antigen-naive and in previously coronavirus disease 2019 (COVID-19)-infected individuals (NCT04743388). Transient increases in interleukin-15 (IL-15) and interferon gamma (IFN-gamma) levels early after boost correlate with Spike antibody levels, supporting their use as biomarkers of effective humoral immunity development in response to vaccination. We identify a systemic signature including increases in IL-15, IFN-gamma, and IP-10/CXCL10 after the 1st vaccination, which were enriched by tumor necrosis factor alpha (TNF-alpha) and IL-6 after the 2nd vaccination. In previously COVID-19-infected individuals, a single vaccination results in both strong cytokine induction and antibody titers similar to the ones observed upon booster vaccination in antigen-naive individuals, a result with potential implication for future public health recommendations.

引用

页数：17

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