Synthesis of a doxycycline-[13CD3] standard

被引：3
作者：
Bupp, James E. [1 ]
Tanga, Mary J. [1 ]
机构：
[1] SRI Int, Biosci Div, 333 Ravenswood Ave, Menlo Pk, CA 94025 USA
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2016年 / 59卷 / 07期
关键词：
MS internal standard; doxycycline; antibiotic; demethylation; N-DEMETHYLATION; ALKALOIDS;
D O I：
10.1002/jlcr.3397
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A stable isotope labelled mass spectrometry internal standard of the antibiotic doxycycline was prepared to assist in pharmacokinetic analyses. Our approach was to first N-demethylate doxycycline using a non-classical Polonovski reaction and then re-methylate using methyl-[(CD3)-C-13] iodide, which gave doxycycline-[(CD3)-C-13] with an isotopic purity of 99%.
引用
收藏
页码：291 / 293
页数：3
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