Off balance: Interferons in COVID-19 lung infections

被引：36

作者：

Akamatsu, Milena ^{[1
]}

de Castro, Tavares ^{[1
]}

Takano, Carolina Yumi ^{[1
]}

Ho, Paulo Lee ^{[1
]}

机构：

[1] Inst Butantan, Ctr BioInd, Nucleo Prod Vacinas Bacterianas, Sao Paulo, Brazil

来源：

EBIOMEDICINE | 2021年 / 73卷

基金：

巴西圣保罗研究基金会;

关键词：

Interferons; Cytokine Storms; SARS-CoV-2; COVID-19; TNF alpha; IMMUNITY; INNATE; GAMMA; EXPRESSION; RESPONSES; DISEASE; PROTEIN; CELLS; BETA;

D O I：

10.1016/j.ebiom.2021.103642

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interferons are innate and adaptive cytokines involved in many biological responses, in particular, viral infections. With the final response the result of the balance of the different types of Interferons. Cytokine storms are physiological reactions observed in humans and animals in which the innate immune system causes an uncontrolled and excessive release of pro-inflammatory signaling molecules. The excessive and prolonged presence of these cytokines can cause tissue damage, multisystem organ failure and death. The role of Interferons in virus clearance, tissue damage and cytokine storms are discussed, in view of COVID-19 caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The imbalance of Type I, Type II and Type III Interferons during a viral infection contribute to the clinical outcome, possibly together with other cytokines, in particular, TNFa, with clear implications for clinical interventions to restore their correct balance. (C) 2021 The Author(s). Published by Elsevier B.V.

引用

页数：7

共 72 条

[71] Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 [J].

Zhang, Qian ;

Bastard, Paul ;

Liu, Zhiyong ;

Le Pen, Jeremie ;

Moncada-Velez, Marcela ;

Chen, Jie ;

Ogishi, Masato ;

Sabli, Ira K. D. ;

Hodeib, Stephanie ;

Korol, Cecilia ;

Rosain, Jeremie ;

Bilguvar, Kaya ;

Ye, Junqiang ;

Bolze, Alexandre ;

Bigio, Benedetta ;

Yang, Rui ;

Arias, Andres Augusto ;

Zhou, Qinhua ;

Zhang, Yu ;

Onodi, Fanny ;

Korniotis, Sarantis ;

Karpf, Lea ;

Philippot, Quentin ;

Chbihi, Marwa ;

Bonnet-Madin, Lucie ;

Dorgham, Karim ;

Smith, Nikaia ;

Schneider, William M. ;

Razooky, Brandon S. ;

Hoffmann, Hans-Heinrich ;

Michailidis, Eleftherios ;

Moens, Leen ;

Han, Ji Eun ;

Lorenzo, Lazaro ;

Bizien, Lucy ;

Meade, Philip ;

Neehus, Anna-Lena ;

Ugurbil, Aileen Camille ;

Corneau, Aurelien ;

Kerner, Gaspard ;

Zhang, Peng ;

Rapaport, Franck ;

Seeleuthner, Yoann ;

Manry, Jeremy ;

Masson, Cecile ;

Schmitt, Yohann ;

Schlueter, Agatha ;

Le Voyer, Tom ;

Khan, Taushif ;

Li, Juan .

SCIENCE, 2020, 370 (6515)

[72] SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues [J].

Ziegler, Carly G. K. ;

Allon, Samuel J. ;

Nyquist, Sarah K. ;

Mbano, Ian M. ;

Miao, Vincent N. ;

Tzouanas, Constantine N. ;

Cao, Yuming ;

Yousif, Ashraf S. ;

Bals, Julia ;

Hauser, Blake M. ;

Feldman, Jared ;

Muus, Christoph ;

Wadsworth, Marc H., II ;

Kazer, Samuel W. ;

Hughes, Travis K. ;

Doran, Benjamin ;

Gatter, G. James ;

Vukovic, Marko ;

Taliaferro, Faith ;

Mead, Benjamin E. ;

Guo, Zhiru ;

Wang, Jennifer P. ;

Gras, Delphine ;

Plaisant, Magali ;

Ansari, Meshal ;

Angelidis, Ilias ;

Adler, Heiko ;

Sucre, Jennifer M. S. ;

Taylor, Chase J. ;

Lin, Brian ;

Waghray, Avinash ;

Mitsialis, Vanessa ;

Dwyer, Daniel F. ;

Buchheit, Kathleen M. ;

Boyce, Joshua A. ;

Barrett, Nora A. ;

Laidlaw, Tanya M. ;

Carroll, Shaina L. ;

Colonna, Lucrezia ;

Tkachev, Victor ;

Peterson, Christopher W. ;

Yu, Alison ;

Zheng, Hengqi Betty ;

Gideon, Hannah P. ;

Winchell, Caylin G. ;

Lin, Philana Ling ;

Bingle, Colin D. ;

Snapper, Scott B. ;

Kropski, Jonathan A. ;

Theis, Fabian J. .

CELL, 2020, 181 (05) :1016-+

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