共 60 条
Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limited scar formation
被引:31
作者:

Nagai, Jun
论文数: 0 引用数: 0
h-index: 0
机构:
Waseda Univ, Grad Sch Adv Sci & Engn, TWIns, Dept Life Sci & Med Biosci, Tokyo 1628480, Japan
Yokohama City Univ, Grad Sch Med, Res Fellow Japan Soc Promot Sci, Yokohama, Kanagawa 2360004, Japan Waseda Univ, Grad Sch Adv Sci & Engn, TWIns, Dept Life Sci & Med Biosci, Tokyo 1628480, Japan

Kitamura, Yoshiteru
论文数: 0 引用数: 0
h-index: 0
机构:
Waseda Univ, Grad Sch Adv Sci & Engn, TWIns, Dept Life Sci & Med Biosci, Tokyo 1628480, Japan Waseda Univ, Grad Sch Adv Sci & Engn, TWIns, Dept Life Sci & Med Biosci, Tokyo 1628480, Japan

Owada, Kazuki
论文数: 0 引用数: 0
h-index: 0
机构:
Waseda Univ, Grad Sch Adv Sci & Engn, TWIns, Dept Life Sci & Med Biosci, Tokyo 1628480, Japan Waseda Univ, Grad Sch Adv Sci & Engn, TWIns, Dept Life Sci & Med Biosci, Tokyo 1628480, Japan

论文数: 引用数:
h-index:
机构:

Takei, Kohtaro
论文数: 0 引用数: 0
h-index: 0
机构:
Yokohama City Univ, Grad Sch Med Life Sci, Dept Med Life Sci, Yokohama, Kanagawa 2360004, Japan Waseda Univ, Grad Sch Adv Sci & Engn, TWIns, Dept Life Sci & Med Biosci, Tokyo 1628480, Japan

Goshima, Yoshio
论文数: 0 引用数: 0
h-index: 0
机构:
Yokohama City Univ, Grad Sch Med, Dept Mol Pharmacol & Neurobiol, Yokohama, Kanagawa 2360004, Japan Waseda Univ, Grad Sch Adv Sci & Engn, TWIns, Dept Life Sci & Med Biosci, Tokyo 1628480, Japan

Ohshima, Toshio
论文数: 0 引用数: 0
h-index: 0
机构:
Waseda Univ, Grad Sch Adv Sci & Engn, TWIns, Dept Life Sci & Med Biosci, Tokyo 1628480, Japan Waseda Univ, Grad Sch Adv Sci & Engn, TWIns, Dept Life Sci & Med Biosci, Tokyo 1628480, Japan
机构:
[1] Waseda Univ, Grad Sch Adv Sci & Engn, TWIns, Dept Life Sci & Med Biosci, Tokyo 1628480, Japan
[2] Yokohama City Univ, Grad Sch Med, Res Fellow Japan Soc Promot Sci, Yokohama, Kanagawa 2360004, Japan
[3] Yokohama City Univ, Grad Sch Med, Dept Mol Pharmacol & Neurobiol, Yokohama, Kanagawa 2360004, Japan
[4] Yokohama City Univ, Grad Sch Med Life Sci, Dept Med Life Sci, Yokohama, Kanagawa 2360004, Japan
来源:
SCIENTIFIC REPORTS
|
2015年
/
5卷
关键词:
MYELIN-ASSOCIATED INHIBITORS;
AXONAL REGENERATION;
FUNCTIONAL RECOVERY;
CHONDROITINASE ABC;
APOPTOSIS;
CONTRIBUTE;
OUTGROWTH;
RHO;
DEGENERATION;
INFLAMMATION;
D O I:
10.1038/srep08269
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Axonal outgrowth inhibitors and scar formation are two major obstacles to central nervous system (CNS) repair. No target molecule that regulates both axonal growth and scarring has been identified. Here we identified collapsin response mediator protein 4 (CRMP4), a common mediator of inhibitory signals after neural injury, as a crucial factor that contributes to both axonal growth inhibition and scarring after spinal cord injury (SCI). We found increases in the inhibitory and toxic forms of CRMP4 in injured spinal cord. Notably, CRMP4 expression was evident in inflammatory cells as well as in neurons after spinal cord transection. Crmp4(-/-) mice displayed neuroprotection against SCI and reductions in inflammatory response and scar formation. This permissive environment for axonal growth due to CRMP4 deletion restored locomotor activity at an unusually early phase of healing. These results suggest that deletion of CRMP4 is a unique therapeutic strategy that overcomes two obstacles to CNS repair after SCI.
引用
收藏
页数:12
相关论文
共 60 条
[1]
Identification of CRMP4 as a convergent regulator of axon outgrowth inhibition
[J].
Alabed, Yazan Z.
;
Pool, Madeline
;
Tone, Stephan Ong
;
Fournier, Alyson E.
.
JOURNAL OF NEUROSCIENCE,
2007, 27 (07)
:1702-1711

Alabed, Yazan Z.
论文数: 0 引用数: 0
h-index: 0
机构:
Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada

Pool, Madeline
论文数: 0 引用数: 0
h-index: 0
机构:
Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada

Tone, Stephan Ong
论文数: 0 引用数: 0
h-index: 0
机构:
Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada

Fournier, Alyson E.
论文数: 0 引用数: 0
h-index: 0
机构:
Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada
[2]
GSK3β Regulates Myelin-Dependent Axon Outgrowth Inhibition through CRMP4
[J].
Alabed, Yazan Z.
;
Pool, Madeline
;
Tone, Stephan Ong
;
Sutherland, Calum
;
Fournier, Alyson E.
.
JOURNAL OF NEUROSCIENCE,
2010, 30 (16)
:5635-5643

Alabed, Yazan Z.
论文数: 0 引用数: 0
h-index: 0
机构:
McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada

Pool, Madeline
论文数: 0 引用数: 0
h-index: 0
机构:
McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada

Tone, Stephan Ong
论文数: 0 引用数: 0
h-index: 0
机构:
McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada

论文数: 引用数:
h-index:
机构:

Fournier, Alyson E.
论文数: 0 引用数: 0
h-index: 0
机构:
McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada
[3]
PROTEOLYTIC-ENZYMES IN EXPERIMENTAL SPINAL-CORD INJURY
[J].
BANIK, NL
;
HOGAN, EL
;
POWERS, JM
;
SMITH, KP
.
JOURNAL OF THE NEUROLOGICAL SCIENCES,
1986, 73 (03)
:245-256

BANIK, NL
论文数: 0 引用数: 0
h-index: 0
机构:
MED UNIV S CAROLINA, DEPT PATHOL NEUROPATHOL, CHARLESTON, SC 29425 USA MED UNIV S CAROLINA, DEPT PATHOL NEUROPATHOL, CHARLESTON, SC 29425 USA

HOGAN, EL
论文数: 0 引用数: 0
h-index: 0
机构:
MED UNIV S CAROLINA, DEPT PATHOL NEUROPATHOL, CHARLESTON, SC 29425 USA MED UNIV S CAROLINA, DEPT PATHOL NEUROPATHOL, CHARLESTON, SC 29425 USA

POWERS, JM
论文数: 0 引用数: 0
h-index: 0
机构:
MED UNIV S CAROLINA, DEPT PATHOL NEUROPATHOL, CHARLESTON, SC 29425 USA MED UNIV S CAROLINA, DEPT PATHOL NEUROPATHOL, CHARLESTON, SC 29425 USA

SMITH, KP
论文数: 0 引用数: 0
h-index: 0
机构:
MED UNIV S CAROLINA, DEPT PATHOL NEUROPATHOL, CHARLESTON, SC 29425 USA MED UNIV S CAROLINA, DEPT PATHOL NEUROPATHOL, CHARLESTON, SC 29425 USA
[4]
Basso mouse scale for locomotion detects differences in recovery after spinal cord in ury in five common mouse strains
[J].
Basso, DM
;
Fisher, LC
;
Anderson, AJ
;
Jakeman, LB
;
McTigue, DM
;
Popovich, PG
.
JOURNAL OF NEUROTRAUMA,
2006, 23 (05)
:635-659

Basso, DM
论文数: 0 引用数: 0
h-index: 0
机构: Ohio State Univ, Div Phys Therapy, Sch Allied Med Profess, Columbus, OH 43210 USA

Fisher, LC
论文数: 0 引用数: 0
h-index: 0
机构: Ohio State Univ, Div Phys Therapy, Sch Allied Med Profess, Columbus, OH 43210 USA

Anderson, AJ
论文数: 0 引用数: 0
h-index: 0
机构: Ohio State Univ, Div Phys Therapy, Sch Allied Med Profess, Columbus, OH 43210 USA

Jakeman, LB
论文数: 0 引用数: 0
h-index: 0
机构: Ohio State Univ, Div Phys Therapy, Sch Allied Med Profess, Columbus, OH 43210 USA

McTigue, DM
论文数: 0 引用数: 0
h-index: 0
机构: Ohio State Univ, Div Phys Therapy, Sch Allied Med Profess, Columbus, OH 43210 USA

Popovich, PG
论文数: 0 引用数: 0
h-index: 0
机构: Ohio State Univ, Div Phys Therapy, Sch Allied Med Profess, Columbus, OH 43210 USA
[5]
Review of current evidence for apoptosis after spinal cord injury
[J].
Beattie, MS
;
Farooqui, AA
;
Bresnahan, JC
.
JOURNAL OF NEUROTRAUMA,
2000, 17 (10)
:915-925

Beattie, MS
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Med Ctr, Dept Neurosci, Lab CNS Repair, Columbus, OH 43212 USA Ohio State Univ, Med Ctr, Dept Neurosci, Lab CNS Repair, Columbus, OH 43212 USA

Farooqui, AA
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Med Ctr, Dept Neurosci, Lab CNS Repair, Columbus, OH 43212 USA Ohio State Univ, Med Ctr, Dept Neurosci, Lab CNS Repair, Columbus, OH 43212 USA

Bresnahan, JC
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Med Ctr, Dept Neurosci, Lab CNS Repair, Columbus, OH 43212 USA Ohio State Univ, Med Ctr, Dept Neurosci, Lab CNS Repair, Columbus, OH 43212 USA
[6]
Chondroitinase ABC promotes functional recovery after spinal cord injury
[J].
Bradbury, EJ
;
Moon, LDF
;
Popat, RJ
;
King, VR
;
Bennett, GS
;
Patel, PN
;
Fawcett, JW
;
McMahon, SB
.
NATURE,
2002, 416 (6881)
:636-640

Bradbury, EJ
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll London, Ctr Res Neurosci, Sensory Funct Grp, London SE1 1UL, England

Moon, LDF
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll London, Ctr Res Neurosci, Sensory Funct Grp, London SE1 1UL, England

Popat, RJ
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll London, Ctr Res Neurosci, Sensory Funct Grp, London SE1 1UL, England

King, VR
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll London, Ctr Res Neurosci, Sensory Funct Grp, London SE1 1UL, England

Bennett, GS
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll London, Ctr Res Neurosci, Sensory Funct Grp, London SE1 1UL, England

Patel, PN
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll London, Ctr Res Neurosci, Sensory Funct Grp, London SE1 1UL, England

Fawcett, JW
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll London, Ctr Res Neurosci, Sensory Funct Grp, London SE1 1UL, England

McMahon, SB
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll London, Ctr Res Neurosci, Sensory Funct Grp, London SE1 1UL, England
[7]
Manipulating the glial scar: Chondroitinase ABC as a therapy for spinal cord injury
[J].
Bradbury, Elizabeth J.
;
Carter, Lucy M.
.
BRAIN RESEARCH BULLETIN,
2011, 84 (4-5)
:306-316

Bradbury, Elizabeth J.
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Wolfson Ctr Age Related Dis, Neurorestorat Grp, London SE1 1UL, England Kings Coll London, Wolfson Ctr Age Related Dis, Neurorestorat Grp, London SE1 1UL, England

Carter, Lucy M.
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Wolfson Ctr Age Related Dis, Neurorestorat Grp, London SE1 1UL, England Kings Coll London, Wolfson Ctr Age Related Dis, Neurorestorat Grp, London SE1 1UL, England
[8]
Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism
[J].
Cai, DM
;
Shen, YJ
;
De Bellard, M
;
Tang, S
;
Filbin, MT
.
NEURON,
1999, 22 (01)
:89-101

Cai, DM
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY Hunter Coll, Dept Biol, New York, NY 10021 USA CUNY Hunter Coll, Dept Biol, New York, NY 10021 USA

Shen, YJ
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY Hunter Coll, Dept Biol, New York, NY 10021 USA CUNY Hunter Coll, Dept Biol, New York, NY 10021 USA

De Bellard, M
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY Hunter Coll, Dept Biol, New York, NY 10021 USA CUNY Hunter Coll, Dept Biol, New York, NY 10021 USA

Tang, S
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY Hunter Coll, Dept Biol, New York, NY 10021 USA CUNY Hunter Coll, Dept Biol, New York, NY 10021 USA

Filbin, MT
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY Hunter Coll, Dept Biol, New York, NY 10021 USA CUNY Hunter Coll, Dept Biol, New York, NY 10021 USA
[9]
The Yellow Fluorescent Protein (YFP-H) Mouse Reveals Neuroprotection as a Novel Mechanism Underlying Chondroitinase ABC-Mediated Repair after Spinal Cord Injury
[J].
Carter, Lucy M.
;
Starkey, Michelle L.
;
Akrimi, Sonia F.
;
Davies, Meirion
;
McMahon, Stephen B.
;
Bradbury, Elizabeth J.
.
JOURNAL OF NEUROSCIENCE,
2008, 28 (52)
:14107-14120

Carter, Lucy M.
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Wolfson Ctr Age Related Dis, Neurorestorat Grp, London SE1 1UL, England Kings Coll London, Wolfson Ctr Age Related Dis, Neurorestorat Grp, London SE1 1UL, England

Starkey, Michelle L.
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Wolfson Ctr Age Related Dis, Neurorestorat Grp, London SE1 1UL, England Kings Coll London, Wolfson Ctr Age Related Dis, Neurorestorat Grp, London SE1 1UL, England

Akrimi, Sonia F.
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Wolfson Ctr Age Related Dis, Neurorestorat Grp, London SE1 1UL, England Kings Coll London, Wolfson Ctr Age Related Dis, Neurorestorat Grp, London SE1 1UL, England

Davies, Meirion
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Wolfson Ctr Age Related Dis, Neurorestorat Grp, London SE1 1UL, England Kings Coll London, Wolfson Ctr Age Related Dis, Neurorestorat Grp, London SE1 1UL, England

McMahon, Stephen B.
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Wolfson Ctr Age Related Dis, Neurorestorat Grp, London SE1 1UL, England Kings Coll London, Wolfson Ctr Age Related Dis, Neurorestorat Grp, London SE1 1UL, England

Bradbury, Elizabeth J.
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Wolfson Ctr Age Related Dis, Neurorestorat Grp, London SE1 1UL, England Kings Coll London, Wolfson Ctr Age Related Dis, Neurorestorat Grp, London SE1 1UL, England
[10]
Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo
[J].
Cole, Adam R.
;
Causeret, Frederic
;
Yadirgi, Gokhan
;
Hastie, C. James
;
McLauchlan, Hilary
;
McManus, Edward J.
;
Hernandez, Felix
;
Eickholt, Britta J.
;
Nikolic, Margareta
;
Sutherland, Calum
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2006, 281 (24)
:16591-16598

Cole, Adam R.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dundee, Ninewells Hosp, Div Pathol & Neurosci, Dundee DD1 9SY, Scotland

Causeret, Frederic
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dundee, Ninewells Hosp, Div Pathol & Neurosci, Dundee DD1 9SY, Scotland

Yadirgi, Gokhan
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dundee, Ninewells Hosp, Div Pathol & Neurosci, Dundee DD1 9SY, Scotland

Hastie, C. James
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dundee, Ninewells Hosp, Div Pathol & Neurosci, Dundee DD1 9SY, Scotland

McLauchlan, Hilary
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dundee, Ninewells Hosp, Div Pathol & Neurosci, Dundee DD1 9SY, Scotland

McManus, Edward J.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dundee, Ninewells Hosp, Div Pathol & Neurosci, Dundee DD1 9SY, Scotland

Hernandez, Felix
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dundee, Ninewells Hosp, Div Pathol & Neurosci, Dundee DD1 9SY, Scotland

Eickholt, Britta J.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dundee, Ninewells Hosp, Div Pathol & Neurosci, Dundee DD1 9SY, Scotland

Nikolic, Margareta
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dundee, Ninewells Hosp, Div Pathol & Neurosci, Dundee DD1 9SY, Scotland

Sutherland, Calum
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Dundee, Ninewells Hosp, Div Pathol & Neurosci, Dundee DD1 9SY, Scotland Univ Dundee, Ninewells Hosp, Div Pathol & Neurosci, Dundee DD1 9SY, Scotland