Molecular Characterization and Meta-Analysis of Gut Microbial Communities Illustrate Enrichment of Prevotella and Megasphaera in Indian Subjects

被引:91
作者
Bhute, Shrikant [1 ]
Pande, Pranav [2 ]
Shetty, Sudarshan A. [2 ,7 ]
Shelar, Rahul [2 ]
Mane, Sachin [2 ]
Kumbhare, Shreyas V. [2 ]
Gawali, Ashwini [2 ]
Makhani, Hemal [2 ]
Navandar, Mohit [2 ]
Dhotre, Dhiraj [2 ]
Lubree, Himangi [3 ]
Agarwal, Dhiraj [4 ]
Patil, Rutuja [4 ]
Ozarkar, Shantanu [5 ]
Ghaskadbi, Saroj [1 ]
Yajnik, Chittaranjan [3 ]
Juvekar, Sanjay [4 ]
Makharia, Govind K. [6 ]
Shouche, Yogesh S. [2 ]
机构
[1] Savitribai Phule Pune Univ, Dept Zool, Pune, Maharashtra, India
[2] Savitribai Phule Pune Univ, Natl Ctr Cell Sci, Microbial Culture Collect, Pune, Maharashtra, India
[3] KEM Hosp, Res Ctr, Diabet Unit, Pune, Maharashtra, India
[4] KEM Hosp, Res Ctr, Vadu Rural Hlth Program, Pune, Maharashtra, India
[5] Savitribai Phule Pune Univ, Dept Anthropol, Pune, Maharashtra, India
[6] All India Inst Med Sci, Dept Gastroenterol & Human Nutr, New Delhi, India
[7] Wageningen Univ, Microbiol Lab, NL-6700 AP Wageningen, Netherlands
关键词
Indian subjects; 16S rRNA amplicon; qPCR; Prevotella and Megasphaera; FECAL MICROBIOTA; COLONIZATION; POPULATIONS; GENERATION; SEQUENCES; GENOMES; UNIFRAC; DIET; ASIA; AGE;
D O I
10.3389/fmicb.2016.00660
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The gut microbiome has varied impact on the wellbeing of humans. It is influenced by different factors such as age, dietary habits, socio-economic status, geographic location, and genetic makeup of individuals. For devising microbiome-based therapies, it is crucial to identify population specific features of the gut microbiome. Indian population is one of the most ethnically, culturally, and geographically diverse, but the gut microbiome features remain largely unknown. The present study describes gut microbial communities of healthy Indian subjects and compares it with the microbiota from other populations. Based on large differences in alpha diversity indices, abundance of 11 bacterial phyla and individual specific OTUs, we report inter-individual variations in gut microbial communities of these subjects. While the gut microbiome of Indians is different from that of Americans, it shared high similarity to individuals from the Indian subcontinent i.e., Bangladeshi. Distinctive feature of Indian gut microbiota is the predominance of genus Prevotella and Megasphaera. Further, when compared with other non-human primates, it appears that Indians share more OTUs with omnivorous mammals. Our metagenomic imputation indicates higher potential for glycan biosynthesis and xenobiotic metabolism in these subjects. Our study indicates urgent need of identification of population specific microbiome biomarkers of Indian subpopulations to have more holistic view of the Indian gut microbiome and its health implications.
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页数:14
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