Hepatitis B virus X protein-induced upregulation of CAT-1 stimulates proliferation and inhibits apoptosis in hepatocellular carcinoma cells

被引：24

作者：

Dai, Rongjuan ^{[1
]}

Peng, Feng ^{[1
]}

Xiao, Xinqiang ^{[1
]}

Gong, Xing ^{[1
]}

Jiang, Yongfang ^{[1
]}

Zhang, Min ^{[1
]}

Tian, Yi ^{[1
]}

Xu, Yun ^{[1
]}

Ma, Jing ^{[1
]}

Li, Mingming ^{[1
]}

Luo, Yue ^{[1
]}

Gong, Guozhong ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp 2, Inst Hepatol, Dept Infect Dis, Changsha 410011, Hunan, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 37期

关键词：

HBx; CAT-1; miR-122; Gld2; HCC; AMINO-ACID; TRANSGENIC MICE; LIVER-CANCER; TRANSPORTERS; EXPRESSION; ARGININE; MIR-122; PROGRESSION; GENE;

D O I：

10.18632/oncotarget.17631

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The HBx protein of hepatitis B virus (HBV) is widely recognized to be a critical oncoprotein contributing to the development of HBV-related hepatocellular carcinoma (HCC). In addition, cationic amino acid transporter 1 (CAT-1) gene is a target of miR-122. In this study, we found that CAT-1 protein levels were higher in HBV-related HCC carcinomatous tissues than in para-cancerous tumor tissues, and that CAT-1 promoted HCC cell growth, proliferation, and metastasis. Moreover, HBx-induced decreases in Gld2 and miR-122 levels that contributed to the upregulation of CAT-1 in HCC. These results indicate that a Gld2/miR-122/CAT-1 pathway regulated by HBx likely participates in HBV-related hepatocellular carcinogenesis.

引用

页码：60962 / 60974

页数：13

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