Reduction of vasopressor requirement by hydrocortisone administration in a patient with cerebral vasospasm

被引：2

作者：

Alhashemi, JA ^{[1
]}

机构：

[1] Univ Western Ontario, Hlth Sci Ctr, Div Crit Care Med, London, ON N6A 5A5, Canada

来源：

BRITISH JOURNAL OF ANAESTHESIA | 2001年 / 86卷 / 01期

关键词：

sympathetic nervous system; phenylephrine; receptors; adrenergic; complications; tachyphylaxis;

D O I：

10.1093/bja/86.1.138

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

A 67-yr-old female received hypertensive, hypervolaemic treatment for cerebral vasospasm after severe subarachnoid haemorrhage. After 3 days of continuous vasopressor infusion and despite adequate hydration and normal cardiac function, the phenylephrine dose had to be increased to:obtain the same systolic blood pressure. This tachyphylaxis to phenylephrine infusion was probably caused by down-regulation of ct adrenoceptors, and was reversed by giving i.v. hydrocortisone.

引用

页码：138 / 141

页数：4

共 20 条

[1] CLINICAL VASOSPASM AFTER SUBARACHNOID HEMORRHAGE - RESPONSE TO HYPERVOLEMIC HEMODILUTION AND ARTERIAL-HYPERTENSION [J].

AWAD, IA ;

CARTER, LP ;

SPETZLER, RF ;

MEDINA, M ;

WILLIAMS, FW .

STROKE, 1987, 18 (02) :365-372

[2] Concomitant inhaled corticosteroid resensitises cardiac β2-adrenoceptors in the presence of long-acting β2-agonist therapy [J].

Aziz, I ;

McFarlane, LC ;

Lipworth, BJ .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1998, 54 (05) :377-381

[3] Reversal of late septic shock with supraphysiologic doses of hydrocortisone [J].

Bollaert, PE ;

Charpentier, C ;

Levy, B ;

Debouverie, M ;

Audibert, G ;

Larcan, A .

CRITICAL CARE MEDICINE, 1998, 26 (04) :645-650

[4] SELECTIVE DOWN REGULATION OF VASCULAR-BETA1 ADRENERGIC-RECEPTORS AFTER PROLONGED ISOPROTERENOL INFUSION [J].

COHEN, ML ;

SCHENCK, KW .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1987, 10 (03) :365-368

[5]

GENGO PJ, 1988, J PHARMACOL EXP THER, V244, P100

[6]

HAYES JS, 1986, J PHARMACOL EXP THER, V237, P757

[7] BETA-ADRENERGIC-RECEPTOR REPOPULATION OF C6-GLIOMA CELLS AFTER IRREVERSIBLE BLOCKADE AND DOWN REGULATION [J].

HOMBURGER, V ;

PANTALONI, C ;

LUCAS, M ;

GOZLAN, H ;

BOCKAERT, J .

JOURNAL OF CELLULAR PHYSIOLOGY, 1984, 121 (03) :589-597

[8] SURGICAL RISK AS RELATED TO TIME OF INTERVENTION IN REPAIR OF INTRACRANIAL ANEURYSMS [J].

HUNT, WE ;

HESS, RM .

JOURNAL OF NEUROSURGERY, 1968, 28 (01) :14-&

[9] BETA-ADRENERGIC RECEPTORS IN CONGESTIVE HEART-FAILURE - PRESENT KNOWLEDGE AND FUTURE-DIRECTIONS [J].

MAISEL, AS ;

MICHEL, MC .

CARDIOLOGY, 1989, 76 (05) :338-346

[10] PROTECTIVE EFFECTS OF A GLUCOCORTICOID ON DOWN-REGULATION OF PULMONARY BETA(2)-ADRENERGIC RECEPTORS IN-VIVO [J].

MAK, JCW ;

NISHIKAWA, M ;

SHIRASAKI, H ;

MIYAYASU, K ;

BARNES, PJ .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (01) :99-106

← 1 2 →