Risk factors for venous thromboembolism after lung transplantation

被引：50
作者：
Yegen, Hilary A.
Lederer, David J.
Barr, R. Graham
Wilt, Jessie S.
Fang, Yixin
Bagiella, Emilia
D'Ovidio, Frank
Okun, Jeffrey M.
Sonett, Joshua R.
Arcasoy, Selint M.
Kawut, Steven M.
机构：
[1] Columbia Univ Coll Phys & Surg, Div Pulm Allergy & Crit Care Med, Dept Med, New York, NY 10032 USA
[2] Columbia Univ Coll Phys & Surg, Dept Surg, New York, NY 10032 USA
[3] Columbia Univ Coll Phys & Surg, Grad Sch Arts & Sci, Dept Stat, New York, NY 10032 USA
[4] Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY USA
来源：
CHEST | 2007年 / 132卷 / 02期
关键词：
long transplantation; pulmonary embolism; venous thrombosis;
D O I：
10.1378/chest.07-0035
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Background: The risk factors for venous thromboembolism (VTE) following lung transplantation are not well established. We aimed to estimate the incidence of VTE and to identify the risk factors for VTE after lung transplantation. Methods: We performed a nested case-control study within the cohort of 121 patients who underwent lung transplantation at our center between August 2001 and July 2005. Control subjects were matched to case patients on the number, of days from the time of transplant. Cox proportional hazards models were used to identify risk factors for VTE. Results: Twenty-four patients had deep vein thromboses, and 6 patients had pulmonary emboli (3 patients had both) [22% of the cohort]. In multivariate models, older age (p < 0.05), diabetes mellitus (p = 0.03), and pneumonia (p = 0.02) were associated with a higher rate of VTE. Conclusions: VTE is a frequent complication of lung transplantation. Older age, diabetes, and pneumonia increase the rate of VTE. Future studies of intensive VTE prophylaxis may be warranted.
引用
收藏
页码：547 / 553
页数：7
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