Zwitterion-coated ultrasmall iron oxide nanoparticles for enhanced T1-weighted magnetic resonance imaging applications

被引：69
作者：
Ma, Dan [1 ]
Chen, Jingwen [2 ]
Luo, Yu [1 ]
Wang, Han [2 ,3 ]
Shi, Xiangyang [1 ,4 ]
机构：
[1] Donghua Univ, State Key Lab Modificat Chem Fibers & Polymer Mat, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Dept Radiol, Shanghai 200080, Peoples R China
[3] Natl Engn Res Ctr Nanotechnol, Shanghai 200241, Peoples R China
[4] Univ Madeira, CQM, Campus Penteada, P-9000390 Funchal, Portugal
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2017年 / 5卷 / 35期
基金：
中国国家自然科学基金;
关键词：
ENTRAPPED GOLD NANOPARTICLES; GADOLINIUM-BASED CONTRAST; BIOMEDICAL APPLICATIONS; SURFACE MODIFICATION; FE3O4; NANOPARTICLES; T-1; CONTRAST; AGENTS; TUMORS; MRI; FUNCTIONALIZATION;
D O I：
10.1039/c7tb01588g
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
We report a convenient strategy to prepare ultrasmall Fe3O4 nanoparticles (NPs) coated with zwitterion L-cysteine (Cys) for enhanced T-1-weighted magnetic resonance (MR) imaging applications. The formed Fe3O4-PEG-Cys NPs possess antifouling properties, good r(1) relaxivity, excellent cytocompatibility and hemocompatibility, and can be used as a contrast agent for enhanced blood pool and tumor MR imaging.
引用
收藏
页码：7267 / 7273
页数：7
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