Graft-versus-host disease

被引：0
作者：
Sauer, M. [1 ]
机构：
[1] Hannover Med Sch, Abt Padiat Hamatol & Onkol, D-30625 Hannover, Germany
来源：
MONATSSCHRIFT KINDERHEILKUNDE | 2007年 / 155卷 / 11期
关键词：
graft-versus-host disease; hematopoietic stem cell transplantation; bone marrow transplantation; diagnosis; prophylaxis therapy;
D O I：
10.1007/s00112-007-1612-8
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Graft-versus-host disease (GvHD) is the most important cause for transplant-related morbidity and mortality after hematopoietic stem cell transplantation. Its incidence and severity depend on several factors, such as HLA matching, donor age, source of the graft, and graft manipulation. Significant progress has been made in understanding the pathophysiology of this complication and some of these findings have been implemented in prophylactic or therapeutic approaches that are currently under clinical evaluation. This review summarizes important diagnostic features of GvHD, gives and overview of prophylactic concepts, outlines effective treatment concepts and comments briefly on some innovative therapeutic approaches for patients who fail first line therapy.
引用
收藏
页码：1021 / +
页数：8
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