Recognition of thyroglobulin by T cells: The role of iodine

被引：27
作者：
Carayanniotis, George
机构：
[1] Mem Univ Newfoundland, Fac Med, Div Endocrinol, St John, NF A1B 3V6, Canada
[2] Mem Univ Newfoundland, Fac Med, Div Biomed Sci, St John, NF A1B 3V6, Canada
来源：
THYROID | 2007年 / 17卷 / 10期
关键词：
D O I：
10.1089/thy.2007.0199
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Among known autoantigens, thyroglobulin ( Tg) is unique in its capacity to store iodine, an element provided in our daily diet. Evolutionary pressure has sculpted Tg into a large molecular scaffolding to allow organification of iodide and its incorporation into thyroid hormones. The increase in molecular size and the posttranslational modification by iodine had to exact immunological consequences. Over the last 15 years, numerous Tg peptides - targets of thyroiditogenic T cells - have been mapped, raising questions regarding the mechanisms that maintain or abrogate immune tolerance against this large autoantigen. This review summarizes the work in this area and discusses the role iodine may play in these processes.
引用
收藏
页码：963 / 973
页数：11
相关论文
共 124 条
[1]   THE EFFECT OF IODIDE INGESTION ON THE DEVELOPMENT OF SPONTANEOUS LYMPHOCYTIC THYROIDITIS IN THE DIABETES-PRONE BB/W RAT [J].
ALLEN, EM ;
APPEL, MC ;
BRAVERMAN, LE .
ENDOCRINOLOGY, 1986, 118 (05) :1977-1981
[2]   Expression of self-antigen in the thymus: A little goes a long way [J].
Anderson, AC ;
Kuchroo, VK .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (11) :1627-1629
[3]   Post-translational modifications of self antigens: implications for autoimmunity [J].
Anderton, SM .
CURRENT OPINION IN IMMUNOLOGY, 2004, 16 (06) :753-758
[4]   Distinct regions of thyroglobulin control the proliferation and suppression of thyroid-specific lymphocytes in obese strain chickens [J].
Bagchi, N ;
Sundick, RS ;
Hu, LH ;
Cummings, GD ;
Brown, TR .
ENDOCRINOLOGY, 1996, 137 (08) :3286-3290
[5]   THYROID-CELL INJURY IS AN INITIAL EVENT IN THE INDUCTION OF AUTOIMMUNE-THYROIDITIS BY IODINE IN OBESE STRAIN CHICKENS [J].
BAGCHI, N ;
BROWN, TR ;
SUNDICK, RS .
ENDOCRINOLOGY, 1995, 136 (11) :5054-5060
[6]   INDUCTION OF AUTOIMMUNE-THYROIDITIS IN CHICKENS BY DIETARY IODINE [J].
BAGCHI, N ;
BROWN, TR ;
URDANIVIA, E ;
SUNDICK, RS .
SCIENCE, 1985, 230 (4723) :325-327
[7]   INDUCTION OF EXPERIMENTAL AUTOIMMUNE-THYROIDITIS IN RATS WITH THE SYNTHETIC PEPTIDE (2495-2511) OF THYROGLOBULIN [J].
BALASA, B ;
CARAYANNIOTIS, G .
CELLULAR IMMUNOLOGY, 1993, 148 (02) :259-268
[8]   Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease [J].
Ban, Y ;
Greenberg, DA ;
Concepcion, E ;
Skrabanek, L ;
Villanueva, R ;
Tomer, Y .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (25) :15119-15124
[9]   REGULATION OF EXPERIMENTAL AUTOIMMUNE-THYROIDITIS - MAPPING OF SUSCEPTIBILITY TO THE I-A SUBREGION OF THE MOUSE H-2 [J].
BEISEL, KW ;
DAVID, CS ;
GIRALDO, AA ;
KONG, YM ;
ROSE, NR .
IMMUNOGENETICS, 1982, 15 (04) :427-430
[10]   NECROSIS OF FOLLICULAR CELLS AND DISCHARGE OF THYROIDAL IODINE INDUCED BY ADMINISTERING IODIDE TO IODINE-DEFICIENT DOGS [J].
BELSHAW, BE ;
BECKER, DV .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1973, 36 (03) :466-474
12345678910