Natural products are an important source for proteasome regulating agents

被引：9
作者：
An, Pei [1 ]
Zhang, Li-Jun [1 ]
Peng, Wei [2 ]
Chen, Yu-Ying [1 ]
Liu, Qiu-Ping [1 ]
Luan, Xin [1 ]
Zhang, Hong [1 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, 1200 Cailun Rd, Shanghai 201203, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China
来源：
PHYTOMEDICINE | 2021年 / 93卷
基金：
中国国家自然科学基金;
关键词：
Natural product; Proteasome; Ubiquitin; Protein; Regulation; SQUAMOUS-CELL-CARCINOMA; INHIBITS GLIOBLASTOMA GROWTH; COLON-CANCER CELLS; UBIQUITIN-PROTEASOME; IN-VITRO; DEPENDENT DEGRADATION; DOWN-REGULATION; TANSHINONE IIA; BETA-CATENIN; CYCLIN D1;
D O I：
10.1016/j.phymed.2021.153799
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Background: Natural medicines have a long history in the prevention and treatment of various diseases in East Asian region, especially in China. Modern research has proved that the pharmacological effects of numerous natural medicines involve the participation of ubiquitin proteasome system (UPS). UPS can degrade the unwanted and damaged proteins widely distributed in the nucleus and cytoplasm of various eukaryotes. Purpose: The objective of the present study was to review and discuss the regulatory effects of natural products and extracts on proteasome components, which may help to find new proteasome regulators for drug development and clinical applications. Methods: The related information was compiled using the major scientific databases, such as CNKI, Elsevier, ScienceDirect, PubMed, SpringerLink, Wiley Online, and GeenMedical. The keywords "natural product" and "proteasome" were applied to extract the literature. Nature derived extracts, compounds and their derivatives involved in proteasome regulation were included, and the publications related to synthetic proteasome agents were excluded. Results: The pharmacological effects of more than 80 natural products and extracts derived from phytomedicines related to the proteasome regulation were reviewed. These natural products were classified according to their chemical properties. We also summarized some laws of action of natural products as proteasome regulators in the treatment of diseases, and listed the action characteristics of the typical natural products. Conclusion: Natural products derived from nature can induce the degradation of damaged proteins through UPS or act as regulators to directly regulate the activity of proteasome. But few proteasome modulators are applied clinically. Summary of known rules for proteasome modulators will contribute to discover, modify and synthesize more proteasome modulators for clinical applications.
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页数：17
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