Nanomedicine;
Nanomaterials;
Nanodevice;
Cancer stem cells (CSCs);
Drug delivery;
TARGETED THERAPY;
PHASE-I/II;
IN-VITRO;
REXIN-G;
NANOPARTICLES;
DRUG;
COMBINATION;
DELIVERY;
DOXORUBICIN;
PACLITAXEL;
D O I:
10.1007/s00441-018-2928-5
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Nanomedicine is the spin-off of modern medicine and nanotechnology and aims to prevent and treat diseases using nanoscale materials such as biocompatible nanoparticles and nanorobots. Targeted cellular and tissue-specific clinical applications with maximal therapeutic effects and insignificant side effects could be achieved by the pursuit of nanotechnology in medicine and healthcare regimen. The majority of conventional cancer therapies eliminate the cells of the tumor but not the cancer stem cells (CSCs). Conversely, the use of nanotechnology in CSC-based therapies is an emerging field of biomedical sciences. This article summarizes the recent trends and application of nanomedicine especially in CSC therapy along with its limitations.
机构:
Sichuan Univ, West China Hosp, Joint Res Inst Altitude Hlth, Dept Neurol, Chengdu, Sichuan, Peoples R China
Sichuan Univ, West China Sch Stomatol, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Joint Res Inst Altitude Hlth, Dept Neurol, Chengdu, Sichuan, Peoples R China
He, Ketai
Chen, Mingkun
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Sch Stomatol, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Joint Res Inst Altitude Hlth, Dept Neurol, Chengdu, Sichuan, Peoples R China
Chen, Mingkun
Liu, Jiao
论文数: 0引用数: 0
h-index: 0
机构:
Chengdu Fifth Peoples Hosp, Dept Pharm, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Joint Res Inst Altitude Hlth, Dept Neurol, Chengdu, Sichuan, Peoples R China
Liu, Jiao
Du, Shufang
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Sch Stomatol, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Joint Res Inst Altitude Hlth, Dept Neurol, Chengdu, Sichuan, Peoples R China
Du, Shufang
Ren, Changyu
论文数: 0引用数: 0
h-index: 0
机构:
Chengdu Fifth Peoples Hosp, Dept Pharm, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Joint Res Inst Altitude Hlth, Dept Neurol, Chengdu, Sichuan, Peoples R China
Ren, Changyu
Zhang, Jifa
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, Joint Res Inst Altitude Hlth, Dept Neurol, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Joint Res Inst Altitude Hlth, Dept Neurol, Chengdu, Sichuan, Peoples R China
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Suryaprakash, Smruthi
Lao, Yeh-Hsing
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Lao, Yeh-Hsing
Cho, Hyeon-Yeol
论文数: 0引用数: 0
h-index: 0
机构:
Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Cho, Hyeon-Yeol
Li, Mingqiang
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Li, Mingqiang
Ji, Ha Yeun
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Ji, Ha Yeun
Shao, Dan
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Shao, Dan
Hu, Hanze
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Hu, Hanze
Quek, Chai Hoon
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Quek, Chai Hoon
Huang, Dantong
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Huang, Dantong
Mintz, Rachel L.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Mintz, Rachel L.
Bago, Juli R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Div Mol Pharmaceut, UNC Eshelman Sch Pharm, Chapel Hill, NC 27599 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Bago, Juli R.
Hingtgen, Shawn D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Div Mol Pharmaceut, UNC Eshelman Sch Pharm, Chapel Hill, NC 27599 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Hingtgen, Shawn D.
Lee, Ki-Bum
论文数: 0引用数: 0
h-index: 0
机构:
Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Lee, Ki-Bum
Leong, Kam W.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Columbia Univ, Dept Syst Biol, Med Ctr, New York, NY 10032 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
机构:
Hokkaido Univ, Global Inst Collaborat Res & Educ GI CoRE, Global Stn Quantum Med Sci & Engn, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Global Inst Collaborat Res & Educ GI CoRE, Global Stn Quantum Med Sci & Engn, Sapporo, Hokkaido 0608638, Japan
Wu, Ping-Hsiu
Opadele, Abayomi Emmanuel
论文数: 0引用数: 0
h-index: 0
机构:
Hokkaido Univ, Grad Sch Biomed Sci & Engn, Mol & Cellular Dynam Res, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Global Inst Collaborat Res & Educ GI CoRE, Global Stn Quantum Med Sci & Engn, Sapporo, Hokkaido 0608638, Japan
Opadele, Abayomi Emmanuel
Onodera, Yasuhito
论文数: 0引用数: 0
h-index: 0
机构:
Hokkaido Univ, Global Inst Collaborat Res & Educ GI CoRE, Global Stn Quantum Med Sci & Engn, Sapporo, Hokkaido 0608638, Japan
Hokkaido Univ, Fac Med, Dept Mol Biol, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Global Inst Collaborat Res & Educ GI CoRE, Global Stn Quantum Med Sci & Engn, Sapporo, Hokkaido 0608638, Japan
Onodera, Yasuhito
Nam, Jin-Min
论文数: 0引用数: 0
h-index: 0
机构:
Hokkaido Univ, Global Inst Collaborat Res & Educ GI CoRE, Global Stn Quantum Med Sci & Engn, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Global Inst Collaborat Res & Educ GI CoRE, Global Stn Quantum Med Sci & Engn, Sapporo, Hokkaido 0608638, Japan
机构:
Sogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South KoreaSogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South Korea
Sim, Changbeom
Kim, Haemin
论文数: 0引用数: 0
h-index: 0
机构:
Sogang Univ, Interdisciplinary Program Integrated Biotechnol, Seoul 121742, South KoreaSogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South Korea
Kim, Haemin
Moona, Hyungwon
论文数: 0引用数: 0
h-index: 0
机构:
Sogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South KoreaSogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South Korea
Moona, Hyungwon
Lee, Hohyeon
论文数: 0引用数: 0
h-index: 0
机构:
Sogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South KoreaSogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South Korea
Lee, Hohyeon
论文数: 引用数:
h-index:
机构:
Chang, Jin Ho
Kim, Hyuncheol
论文数: 0引用数: 0
h-index: 0
机构:
Sogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South Korea
Sogang Univ, Interdisciplinary Program Integrated Biotechnol, Seoul 121742, South KoreaSogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South Korea
机构:
Univ Calif San Diego, Dept Radiol, La Jolla, CA 92039 USAUniv Calif San Diego, Dept Radiol, La Jolla, CA 92039 USA
Boone, Christine E.
Wang, Lu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Radiol, La Jolla, CA 92039 USA
Wang, Lu
Gautam, Aayushma
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Radiol, La Jolla, CA 92039 USA
Gautam, Aayushma
Newton, Isabel G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Radiol, La Jolla, CA 92039 USA
Vet Adm San Diego Healthcare Syst, Div Intervent Radiol, San Diego, CA USAUniv Calif San Diego, Dept Radiol, La Jolla, CA 92039 USA
Newton, Isabel G.
Steinmetz, Nicole F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Radiol, La Jolla, CA 92039 USA
Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept NanoEngn, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Ctr Nanoimmunoengn, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Inst Mat Discovery & Design, Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Radiol, La Jolla, CA 92039 USA
机构:
Sichuan Univ, West China Hosp, Joint Res Inst Altitude Hlth, Dept Neurol, Chengdu, Sichuan, Peoples R China
Sichuan Univ, West China Sch Stomatol, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Joint Res Inst Altitude Hlth, Dept Neurol, Chengdu, Sichuan, Peoples R China
He, Ketai
Chen, Mingkun
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Sch Stomatol, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Joint Res Inst Altitude Hlth, Dept Neurol, Chengdu, Sichuan, Peoples R China
Chen, Mingkun
Liu, Jiao
论文数: 0引用数: 0
h-index: 0
机构:
Chengdu Fifth Peoples Hosp, Dept Pharm, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Joint Res Inst Altitude Hlth, Dept Neurol, Chengdu, Sichuan, Peoples R China
Liu, Jiao
Du, Shufang
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Sch Stomatol, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Joint Res Inst Altitude Hlth, Dept Neurol, Chengdu, Sichuan, Peoples R China
Du, Shufang
Ren, Changyu
论文数: 0引用数: 0
h-index: 0
机构:
Chengdu Fifth Peoples Hosp, Dept Pharm, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Joint Res Inst Altitude Hlth, Dept Neurol, Chengdu, Sichuan, Peoples R China
Ren, Changyu
Zhang, Jifa
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, Joint Res Inst Altitude Hlth, Dept Neurol, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Joint Res Inst Altitude Hlth, Dept Neurol, Chengdu, Sichuan, Peoples R China
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Suryaprakash, Smruthi
Lao, Yeh-Hsing
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Lao, Yeh-Hsing
Cho, Hyeon-Yeol
论文数: 0引用数: 0
h-index: 0
机构:
Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Cho, Hyeon-Yeol
Li, Mingqiang
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Li, Mingqiang
Ji, Ha Yeun
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Ji, Ha Yeun
Shao, Dan
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Shao, Dan
Hu, Hanze
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Hu, Hanze
Quek, Chai Hoon
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Quek, Chai Hoon
Huang, Dantong
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Huang, Dantong
Mintz, Rachel L.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Mintz, Rachel L.
Bago, Juli R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Div Mol Pharmaceut, UNC Eshelman Sch Pharm, Chapel Hill, NC 27599 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Bago, Juli R.
Hingtgen, Shawn D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Div Mol Pharmaceut, UNC Eshelman Sch Pharm, Chapel Hill, NC 27599 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Hingtgen, Shawn D.
Lee, Ki-Bum
论文数: 0引用数: 0
h-index: 0
机构:
Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Lee, Ki-Bum
Leong, Kam W.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA
Columbia Univ, Dept Syst Biol, Med Ctr, New York, NY 10032 USAColumbia Univ, Dept Biomed Engn, New York, NY 10027 USA
机构:
Hokkaido Univ, Global Inst Collaborat Res & Educ GI CoRE, Global Stn Quantum Med Sci & Engn, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Global Inst Collaborat Res & Educ GI CoRE, Global Stn Quantum Med Sci & Engn, Sapporo, Hokkaido 0608638, Japan
Wu, Ping-Hsiu
Opadele, Abayomi Emmanuel
论文数: 0引用数: 0
h-index: 0
机构:
Hokkaido Univ, Grad Sch Biomed Sci & Engn, Mol & Cellular Dynam Res, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Global Inst Collaborat Res & Educ GI CoRE, Global Stn Quantum Med Sci & Engn, Sapporo, Hokkaido 0608638, Japan
Opadele, Abayomi Emmanuel
Onodera, Yasuhito
论文数: 0引用数: 0
h-index: 0
机构:
Hokkaido Univ, Global Inst Collaborat Res & Educ GI CoRE, Global Stn Quantum Med Sci & Engn, Sapporo, Hokkaido 0608638, Japan
Hokkaido Univ, Fac Med, Dept Mol Biol, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Global Inst Collaborat Res & Educ GI CoRE, Global Stn Quantum Med Sci & Engn, Sapporo, Hokkaido 0608638, Japan
Onodera, Yasuhito
Nam, Jin-Min
论文数: 0引用数: 0
h-index: 0
机构:
Hokkaido Univ, Global Inst Collaborat Res & Educ GI CoRE, Global Stn Quantum Med Sci & Engn, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Global Inst Collaborat Res & Educ GI CoRE, Global Stn Quantum Med Sci & Engn, Sapporo, Hokkaido 0608638, Japan
机构:
Sogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South KoreaSogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South Korea
Sim, Changbeom
Kim, Haemin
论文数: 0引用数: 0
h-index: 0
机构:
Sogang Univ, Interdisciplinary Program Integrated Biotechnol, Seoul 121742, South KoreaSogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South Korea
Kim, Haemin
Moona, Hyungwon
论文数: 0引用数: 0
h-index: 0
机构:
Sogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South KoreaSogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South Korea
Moona, Hyungwon
Lee, Hohyeon
论文数: 0引用数: 0
h-index: 0
机构:
Sogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South KoreaSogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South Korea
Lee, Hohyeon
论文数: 引用数:
h-index:
机构:
Chang, Jin Ho
Kim, Hyuncheol
论文数: 0引用数: 0
h-index: 0
机构:
Sogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South Korea
Sogang Univ, Interdisciplinary Program Integrated Biotechnol, Seoul 121742, South KoreaSogang Univ, Dept Chem & Biomol Engn, Seoul 121742, South Korea
机构:
Univ Calif San Diego, Dept Radiol, La Jolla, CA 92039 USAUniv Calif San Diego, Dept Radiol, La Jolla, CA 92039 USA
Boone, Christine E.
Wang, Lu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Radiol, La Jolla, CA 92039 USA
Wang, Lu
Gautam, Aayushma
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Radiol, La Jolla, CA 92039 USA
Gautam, Aayushma
Newton, Isabel G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Radiol, La Jolla, CA 92039 USA
Vet Adm San Diego Healthcare Syst, Div Intervent Radiol, San Diego, CA USAUniv Calif San Diego, Dept Radiol, La Jolla, CA 92039 USA
Newton, Isabel G.
Steinmetz, Nicole F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Radiol, La Jolla, CA 92039 USA
Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept NanoEngn, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Ctr Nanoimmunoengn, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Inst Mat Discovery & Design, Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Radiol, La Jolla, CA 92039 USA