Ion transport through chemically induced pores in protein-free phospholipid membranes

被引:29
作者
Gurtovenko, Andrey A. [1 ]
Anwar, Jarnshed [1 ]
机构
[1] Univ Bradford, Inst Pharmaceut Innovat, Computat Lab, Bradford BD7 1DP, W Yorkshire, England
关键词
D O I
10.1021/jp075631v
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
We address the possibility of being able to induce the trafficking of salt ions and other solutes across cell membranes without the use of specific protein-based transporters or pumps. On the basis of realistic atomic-scale molecular dynamics simulations, we demonstrate that transmembrane ionic leakage can be initiated by chemical means, in this instance through addition of dimethyl sulfoxide (DMSO), a solvent widely used in cell biology. Our results provide compelling evidence that the small amphiphilic solute DMSO is able to induce transient defects (water pores) in membranes and to promote a subsequent diffusive pore-mediated transport of salt ions. The findings are consistent with available experimental data and offer a molecularlevel explanation for the experimentally observed activities of DMSO solvent as an efficient penetration enhancer and a cryoprotectant, as well as an analgesic. Our findings suggest that transient pore formation by chemical means could emerge as an important general principle for therapeutics.
引用
收藏
页码:13379 / 13382
页数:4
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