How accurate are the European Union's classifications of chemical substances

被引：26

作者：

Rudén, C ^{[1
]}

Hansson, SO ^{[1
]}

机构：

[1] Royal Inst Technol, Philosophy Unit, S-10044 Stockholm, Sweden

来源：

TOXICOLOGY LETTERS | 2003年 / 144卷 / 02期

关键词：

regulatory toxicology; risk assessment; risk management; mis-classifications; classification and labelling;

D O I：

10.1016/S0378-4274(03)00204-2

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The European Commission has decided on harmonized classifications for a large number of individual chemicals according to its own directive for classification and labeling of dangerous substances. We have compared the harmonized classifications for acute oral toxicity to the acute oral toxicity data available in the RTECS database. Of the 992 substances eligible for this comparison, 15% were assigned a too low danger class and 8% a too high danger class according to the RTECS data. Due to insufficient transparency-scientific documentations of the classification decisions are not available-the causes of this discrepancy can only be hypothesized. We propose that the scientific motivations of future classifications be published and that the apparent over- and underclassifications in the present system be either explained or rectified, according to what are the facts in the matter. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：159 / 172

页数：14