Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing

被引：18

作者：

Barbour, Michele E. ^{[1
]}

Maddocks, Sarah E. ^{[2
]}

Grady, Helena J. ^{[1
,3
]}

Roper, James A. ^{[4
]}

Bass, Mark D. ^{[5
]}

Collins, Andrew M. ^{[3
]}

Dommett, Rachel M. ^{[6
]}

Saunders, Margaret ^{[7
]}

机构：

[1] Univ Bristol, Sch Oral & Dent Sci, Oral Nanosci, Bristol BS8 1TH, Avon, England

[2] Cardiff Metropolitan Univ, Sch Hlth Sci, Cardiff, S Glam, Wales

[3] Univ Bristol, Bristol Ctr Funct Nanomat, Bristol BS8 1TH, Avon, England

[4] Univ Bristol, Sch Biochem, Bristol BS8 1TH, Avon, England

[5] Univ Sheffield, Dept Biomed Sci, Ctr Membrane Interact & Dynam, Sheffield S10 2TN, S Yorkshire, England

[6] Univ Bristol, Sch Clin Sci, Bristol BS8 1TH, Avon, England

[7] Univ Hosp Bristol, Bioengn Innovat & Res Hub BIRCH, Bristol, Avon, England

来源：

NANOMEDICINE | 2016年 / 11卷 / 16期

基金：

英国工程与自然科学研究理事会;

关键词：

antimicrobial; catheter; chlorhexidine; healing; safety; toxicity; wound care; BLOOD-STREAM INFECTIONS; RELEASE; REPAIR;

D O I：

10.2217/nnm-2016-0084

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. Materials & methods: CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Results: Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by E. faecalis. Conclusion: CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure.

引用

页码：2049 / 2057

页数：9

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