Coronavirus Disease 2019 Vaccine Dosage in Children, Adolescents, and Young Adults: Is Less More?

被引：0

作者：

Tobin, Nicole H. ^{[1
]}

Yang, Otto O. ^{[2
,3
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, 10833 Le Conte Ave,MDCC 22 340, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2022年 / 9卷 / 07期

关键词：

COVID-19; vaccination; Dosage; Dosing intervals; Boosters; Myocarditis; Covid-19 vaccination associated myocarditis; children; adolescents; young adults; MESSENGER-RNA VACCINATION; UNITED-STATES; MYOCARDITIS;

D O I：

10.1093/ofid/ofac222

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The lower efficacy of the COVID-19 mRNA vaccines in 5-11 year old children was unexpected. Neutralizing antibody titers elicited by the vaccines in children, adolescents, and young adults suggest that the lower efficacy is not due to the lower dosage. Confirming the efficacy of these vaccines in children, determining if mRNA vaccination strategies are less effective in younger children, as well as optimizing the dosage, dosing intervals, and number of doses needed in children, adolescents, and young adults are critical to improve vaccination strategies for these populations going forward.

引用

页数：3

共 15 条

[1] Serological responses and vaccine effectiveness for extended COVID-19 vaccine schedules in England
Amirthalingam, Gayatri
Bernal, Jamie Lopez
Andrews, Nick J.
Whitaker, Heather
Gower, Charlotte
Stowe, Julia
Tessier, Elise
Subbarao, Sathyavani
Ireland, Georgina
Baawuah, Frances
Linley, Ezra
Warrener, Lenesha
O'Brien, Michelle
Whillock, Corinne
Moss, Paul
Ladhani, Shamez N.
Brown, Kevin E.
Ramsay, Mary E.
[J]. NATURE COMMUNICATIONS, 2021, 12 (01)
[2] Myocarditis With COVID-19 mRNA Vaccines
Bozkurt, Biykem
Kamat, Ishan
Hotez, Peter J.
[J]. CIRCULATION, 2021, 144 (06) : 471 - 484
[3] Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents
Frenck, Robert W., Jr.
Klein, Nicola P.
Kitchin, Nicholas
Gurtman, Alejandra
Absalon, Judith
Lockhart, Stephen
Perez, John L.
Walter, Emmanuel B.
Senders, Shelly
Bailey, Ruth
Swanson, Kena A.
Ma, Hua
Xu, Xia
Koury, Kenneth
Kalina, Warren V.
Cooper, David
Jennings, Timothy
Brandon, Donald M.
Thomas, Stephen J.
Tureci, Ozlem
Tresnan, Dina B.
Mather, Susan
Dormitzer, Philip R.
Sahin, Ugur
Jansen, Kathrin U.
Gruber, William C.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (03) : 239 - 250
[4] Myocarditis after vaccination against covid-19
Gellad, Walid F.
[J]. BMJ-BRITISH MEDICAL JOURNAL, 2021, 375
[5] Immunogenicity of Extended mRNA SARS-CoV-2 Vaccine Dosing Intervals
Grunau, Brian
Goldfarb, DavidM.
Asamoah-Boaheng, Michael
Golding, Liam
Kirkham, Tracy L.
Demers, Paul A.
Lavoie, Pascal M.
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2022, 327 (03): : 279 - 281
[6] Gurtman A., ADVISORY COMMITTEE I, P2021
[7] Previous Infection Combined with Vaccination Produces Neutralizing Antibodies with Potency against SARS-CoV-2 Variants
Ibarrondo, F. Javier
Hofmann, Christian
Ali, Ayub
Ayoub, Paul
Kohn, Donald B.
Yang, Otto O.
[J]. MBIO, 2021, 12 (06):
[8] Jones J., VACC REL BIOL PROD A
[9] Germinal centre-driven maturation of B cell response to mRNA vaccination
Kim, Wooseob
Zhou, Julian Q.
Horvath, Stephen C.
Schmitz, Aaron J.
Sturtz, Alexandria J.
Lei, Tingting
Liu, Zhuoming
Kalaidina, Elizaveta
Thapa, Mahima
Alsoussi, Wafaa B.
Haile, Alem
Klebert, Michael K.
Suessen, Teresa
Parra-Rodriguez, Luis
Mudd, Philip A.
Whelan, Sean P. J.
Middleton, William D.
Teefey, Sharlene A.
Pusic, Iskra
O'Halloran, Jane A.
Presti, Rachel M.
Turner, Jackson S.
Ellebedy, Ali H.
[J]. NATURE, 2022, 604 (7904) : 141 - +
[10] Klein NP, 2022, MMWR-MORBID MORTAL W, V71, P352, DOI 10.15585/mmwr.mm7109e3

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