Anti-malarial drug: the emerging role of artemisinin and its derivatives in liver disease treatment

被引：21
作者：
Xiong, Ye [1 ]
Huang, Jianrong [1 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 1, Dept Infect Dis,Natl Clin Res Ctr Infect Dis,Stat, Sch Med,Collaborat Innovat Ctr Diag & Treatment I, 79 Qingchun Rd, Hangzhou 310003, Peoples R China
来源：
CHINESE MEDICINE | 2021年 / 16卷 / 01期
关键词：
Artemisinin; Liver disease; Malaria; Anti-inflammatory; Apoptosis; MEDIATED INTRINSIC PATHWAY; HEPATOCELLULAR-CARCINOMA; HEPATIC-FIBROSIS; IN-VITRO; DEPENDENT APOPTOSIS; ANTICANCER ACTIVITY; ANTITUMOR-ACTIVITY; SIGNALING PATHWAY; GENE-EXPRESSION; CANCER-THERAPY;
D O I：
10.1186/s13020-021-00489-0
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Artemisinin and its derivatives belong to a family of drugs approved for the treatment of malaria with known clinical safety and efficacy. In addition to its anti-malarial effect, artemisinin displays anti-viral, anti-inflammatory, and anti-cancer effects in vivo and in vitro. Recently, much attention has been paid to the therapeutic role of artemisinin in liver diseases. Several studies suggest that artemisinin and its derivatives can protect the liver through different mechanisms, such as those pertaining to inflammation, proliferation, invasion, metastasis, and induction of apoptosis and autophagy. In this review, we provide a comprehensive discussion of the underlying molecular mechanisms and signaling pathways of artemisinin and its derivatives in treating liver diseases. Further pharmacological research will aid in determining whether artemisinin and its derivatives may serve as promising medicines for the treatment of liver diseases in the future.
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页数：19
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