Effect of metronidazole analogues on Giardia lamblia cultures

被引：20
作者：
Busatti, Haendel G. N. O.
Vieira, Andrea E. D.
Viana, Joao C.
Silva, Hugo E.
Souza-Fagundes, Elaine M.
Martins-Filho, Olindo A.
Alves, Ricardo J.
Gomes, Maria A.
机构：
[1] Univ Fed Minas Gerais, Dept Parasitol, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Fac Farm, Dept Prod Farmaceut, BR-31270901 Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Fac Ciencias, Inst Ciencias Biol, BR-31270901 Belo Horizonte, MG, Brazil
[4] Inst Rene Rachou, Lab Doenca Chagas, Belo Horizonte, MG, Brazil
来源：
PARASITOLOGY RESEARCH | 2007年 / 102卷 / 01期
关键词：
D O I：
10.1007/s00436-007-0723-4
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
We comparatively evaluate the effect of metronidazole (MTZ) and its five analogues on trophozoites of Giardia lamblia axenically growing. The compounds MTZ-Ms, MTZ-I, MTZ-Br, MTZ-N-3, and MTZ-NH3Cl were obtained by molecular modification of the side chain of MTZ. Four of them presented higher giardicidal activity when compared with MTZ. Among them, MTZ-Br and MTZ-I were the most active, without cytotoxic effects against mitogen-activated human peripheral blood mononuclear cells (PBMC). The alteration of MTZ side chain constitutes a fruitful field to develop new drugs for the treatment not only of giardiasis but also of other diseases and signalize that metronidazole analogues are promising candidates as giardicidal and should be further evaluated.
引用
收藏
页码：145 / 149
页数：5
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