Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications

被引：32

作者：

Jansen, Janine ^{[1
,2
]}

Boerakker, Mark J. ^{[3
]}

Heuts, Jean ^{[4
]}

Feijen, Jan ^{[1
,2
]}

Grijpma, Dirk W. ^{[1
,2
,5
,6
]}

机构：

[1] Univ Twente, MIRA Inst Biomed Technol & Tech Med, NL-7500 AE Enschede, Netherlands

[2] Univ Twente, Fac Sci & Technol, Dept Polymer Chem & Biomat, NL-7500 AE Enschede, Netherlands

[3] DSM Ahead, Geleen, Netherlands

[4] DSM Resolve R&D Solut, Geleen, Netherlands

[5] Univ Med Ctr Groningen, Dept Biomed Engn, NL-9700 AD Groningen, Netherlands

[6] Univ Groningen, NL-9700 AD Groningen, Netherlands

来源：

JOURNAL OF CONTROLLED RELEASE | 2010年 / 147卷 / 01期

关键词：

Biodegradable polymer networks; Poly(trimethylene carbonate); Fumaric acid monoethyl ester; N-vinyl-2-pyrrolidone; Vinyl acetate; Photo-crosslinking kinetics; IN-VITRO DEGRADATION; TRIMETHYLENE CARBONATE; BIODEGRADABLE NETWORKS; EPSILON-CAPROLACTONE; CONTROLLED-RELEASE; POLYMERS; BEHAVIOR; INSTABILITY; COPOLYMERS; ANHYDRIDE;

D O I：

10.1016/j.jconrel.2010.06.031

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable polymer networks. The copolymerization reactions were much faster than homopolymerization of the fumarate end-groups of the macromers. The hydrophilicity of the networks could by varied by mixing NW and VAc at different ratios. The prepared network extracts were compatible with NIH 3T3 fibroblasts. Release of vitamin B12, used as a model drug, could be tuned by varying network hydrophilicity and macromer molecular weight. A more hydrophilic and less densely crosslinked network resulted in faster release. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：54 / 61

页数：8

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