The Importance of Cooperation: Partnerless NFAT Induces T Cell Exhaustion

被引：19

作者：

Bengsch, Bertram ^{[1
]}

Wherry, E. John ^{[1
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Microbiol, Inst Immunol, Philadelphia, PA 19104 USA

来源：

IMMUNITY | 2015年 / 42卷 / 02期

关键词：

CHRONIC VIRAL-INFECTION; TRANSCRIPTION FACTOR; PD-1;

D O I：

10.1016/j.immuni.2015.01.023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Downstream of costimulatory pathways, complexes of transcription factors NFAT and AP-1 promote effector T cell differentiation. In this issue of Immunity, Martinez et al. report that monomeric NFAT binding in the absence of a transcriptional partner induces a gene expression program involved in T cell exhaustion.

引用

页码：203 / 205

页数：4

共 10 条

[1] Molecular mechanisms of T cell co-stimulation and co-inhibition [J].

Chen, Lieping ;

Flies, Dallas B. .

NATURE REVIEWS IMMUNOLOGY, 2013, 13 (04) :227-242

[2] Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory [J].

Doering, Travis A. ;

Crawford, Alison ;

Angelosanto, Jill M. ;

Paley, Michael A. ;

Ziegler, Carly G. ;

Wherry, E. John .

IMMUNITY, 2012, 37 (06) :1130-1144

[3]

Kahan SM, 2015, VIROLOGY

[4] The Transcription Factor NFAT Promotes Exhaustion of Activated CD8+ T Cells [J].

Martinez, Gustavo J. ;

Pereira, Renata M. ;

Aijo, Tarmo ;

Kim, Edward Y. ;

Marangoni, Francesco ;

Pipkin, Matthew E. ;

Togher, Susan ;

Heissmeyer, Vigo ;

Zhang, Yi Chen ;

Crotty, Shane ;

Lamperti, Edward D. ;

Ansel, K. Mark ;

Mempel, Thorsten R. ;

Lahdesmaki, Harri ;

Hogan, Patrick G. ;

Rao, Anjana .

IMMUNITY, 2015, 42 (02) :265-278

[5] NFAT, immunity and cancer: a transcription factor comes of age [J].

Mueller, Martin R. ;

Rao, Anjana .

NATURE REVIEWS IMMUNOLOGY, 2010, 10 (09) :645-656

[6] High antigen levels are the cause of T cell exhaustion during chronic viral infection [J].

Mueller, Scott N. ;

Ahmed, Rafi .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (21) :8623-8628

[7] Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection [J].

Paley, Michael A. ;

Kroy, Daniela C. ;

Odorizzi, Pamela M. ;

Johnnidis, Jonathan B. ;

Dolfi, Douglas V. ;

Barnett, Burton E. ;

Bikoff, Elizabeth K. ;

Robertson, Elizabeth J. ;

Lauer, Georg M. ;

Reiner, Steven L. ;

Wherry, E. John .

SCIENCE, 2012, 338 (6111) :1220-1225

[8] Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF [J].

Quigley, Michael ;

Pereyra, Florencia ;

Nilsson, Bjoern ;

Porichis, Filippos ;

Fonseca, Catia ;

Eichbaum, Quentin ;

Julg, Boris ;

Jesneck, Jonathan L. ;

Brosnahan, Kathleen ;

Imam, Sabrina ;

Russell, Kate ;

Toth, Ildiko ;

Piechocka-Trocha, Alicja ;

Dolfi, Douglas ;

Angelosanto, Jill ;

Crawford, Alison ;

Shin, Haina ;

Kwon, Douglas S. ;

Zupkosky, Jennifer ;

Francisco, Loise ;

Freeman, Gordon J. ;

Wherry, E. John ;

Kaufmann, Daniel E. ;

Walker, Bruce D. ;

Ebert, Benjamin ;

Haining, W. Nicholas .

NATURE MEDICINE, 2010, 16 (10) :1147-U127

[9] The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection [J].

Staron, Matthew M. ;

Gray, Simon M. ;

Marshall, Heather D. ;

Parish, Ian A. ;

Chen, Jonathan H. ;

Perry, Curtis J. ;

Cui, Guoliang ;

Li, Ming O. ;

Kaech, Susan M. .

IMMUNITY, 2014, 41 (05) :802-814

[10] 4-1BB Signaling Synergizes with Programmed Death Ligand 1 Blockade To Augment CD8 T Cell Responses during Chronic Viral Infection [J].

Vezys, Vaiva ;

Penaloza-MacMaster, Pablo ;

Barber, Daniel L. ;

Ha, Sang-Jun ;

Konieczny, Bogumila ;

Freeman, Gordon J. ;

Mittler, Robert S. ;

Ahmed, Rafi .

JOURNAL OF IMMUNOLOGY, 2011, 187 (04) :1634-1642

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