Anti-Ku antibodies: Clinical, genetic and diagnostic insights

被引：43

作者：

Belizna, C. ^{[1
,2
]}

Henrion, D. ^{[2
]}

Beucher, A. ^{[1
]}

Lavigne, C. ^{[1
]}

Ghaali, A. ^{[1
]}

Levesque, H. ^{[3
]}

机构：

[1] Univ Hosp Angers, Dept Internal Med, F-49000 Angers, France

[2] INSERM 771, F-49000 Angers, France

[3] Univ Hosp Rouen, Dept Internal Med, F-76000 Rouen, France

来源：

AUTOIMMUNITY REVIEWS | 2010年 / 9卷 / 10期

关键词：

DEPENDENT PROTEIN-KINASE; SYSTEMIC-LUPUS-ERYTHEMATOSUS; AUTOIMMUNE-DISEASES; CATALYTIC SUBUNIT; BREAK REPAIR; DNA-REPAIR; AUTOANTIBODIES; MYOSITIS; SCLEROSIS; COMPLEX;

D O I：

10.1016/j.autrev.2010.05.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anti-Ku antibodies are reported in various connective tissue diseases and the Ku complex can be responsible for a very strong autoimmune answer in autoimmune disease. Nowadays, anti-Ku antibodies are detected by ELISA, counterimmunoelectrophoresis (CIE), immunoblot (IB) and new highly performant techniques. Although the prevalence of anti-Ku antibodies is not homogenous, depending on several features such as disease type, genetic and geographical clustering, and also method of detection, they could be found in 55% overlap PM/systemic sclerosis patients. Moreover, anti-Ku antibodies are not associated with a particular clinical outcome, and especially with cancer related to myositis. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：691 / 694

页数：4

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