Ammonia in Ugi reactions - Four-component versus six-component couplings

被引：50

作者：

Pick, R ^{[1
]}

Bauer, M ^{[1
]}

Kazmaier, U ^{[1
]}

Hebach, C ^{[1
]}

机构：

[1] Univ Saarland, Inst Organ Chem, D-66041 Saarbrucken, Germany

来源：

SYNLETT | 2005年 / 05期

关键词：

ammonia; peptide; Ugi reactions; six-component coupling;

D O I：

10.1055/s-2005-863722

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

If ammonia is used as amine component in Ugi reactions, the desired peptide sometimes is obtained only as the minor product or in traces. Side reactions such as six-component couplings are responsible for this observation. These side reactions can be suppressed or favoured depending on the reaction conditions used.

引用

页码：757 / 760

页数：4

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