Familial Childhood Monosomy 7 and Associated Myelodysplasia

被引：11

作者：

Gaitonde, Sujata ^{[1
]}

Boumendjel, Redouane ^{[1
]}

Angeles, Ronald ^{[1
]}

Rondelli, Damiano ^{[1
]}

机构：

[1] Univ Illinois, Dept Pathol & Med, Coll Med, Chicago, IL 60612 USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2010年 / 32卷 / 06期

关键词：

monosomy; familial; myelodysplasia; ACUTE MYELOID-LEUKEMIA; PARENTAL ORIGIN; ANEMIA; CHROMOSOME-7; DELETION;

D O I：

10.1097/MPH.0b013e3181e75759

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Familial monosomy 7 is defined as bone marrow monosomy 7 occurring as a sole cytogenetic abnormality affecting 2 or more siblings. It manifests usually in childhood with neurologic disorder (cerebellar ataxia or atrophy) and/or hematologic disorder (marrow hypoplasia, myelodysplasia, acute myeloid leukemia, or pancytopenia). Partial or complete monosomy 7 with hematologic disorder has been reported in 13 families/pedigrees to date. Here we report the 14th family.

引用

页码：E236 / E237

页数：2

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