Adenosquamous carcinoma of the lung

被引：85
作者：
Li, Chenghui [1 ,2 ]
Lu, Hongyang [2 ,3 ]
机构：
[1] Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Canc Hosp, Dept Thorac Med Oncol, Hangzhou, Zhejiang, Peoples R China
[3] Zhejiang Canc Hosp, Zhejiang Key Lab Diag & Treatment Technol Thorac, 1 East Banshan Rd, Hangzhou 310022, Zhejiang, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2018年 / 11卷
关键词：
adenosquamous carcinoma of the lung; clinicopathological characteristics; histogenesis; prognosis; chemotherapy; targeted therapy; immunotherapy; SQUAMOUS-CELL CARCINOMA; GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITORS; THYMIDYLATE-SYNTHASE; 1ST-LINE TREATMENT; OPEN-LABEL; MUTATIONS; EGFR; ADENOCARCINOMA; CANCER;
D O I：
10.2147/OTT.S164574
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Adenosquamous carcinoma of the lung (ASC), a relatively rare subtype of non-small-cell lung cancer, is defined as a malignancy containing components of lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SCC). Although ASC has biological characteristics of ADC and SCC, it is not by any means a simple hybrid of two components above. It is extremely difficult to diagnose preoperatively; pathology of surgically resected gross specimen is the most effective means for adequate diagnosis of ASC. Platinum-based postoperative adjuvant chemotherapy for at least four cycles can significantly improve the survival in stage III patients with ASC. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) such as erlotinib and gefitinib can be the effective therapeutic strategies for advanced EGFRmutant ASC. The studies of crizotinib in the treatment of patients with ASC are very limited. Immune checkpoint blockade therapy may be a potential treatment choice for ASC patients.
引用
收藏
页码：4829 / 4835
页数：7
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