Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases

被引：39
|
作者：
Valente, Sergio [1 ]
Bana, Emilie [1 ]
Viry, Elodie [1 ]
Bagrel, Denyse [1 ]
Kirsch, Gilbert [1 ]
机构：
[1] Univ Paul Verlaine, Lab Ingenierie Mol & Biochim Pharmacol, Inst Jean Barriol, FR CNRS 2843, F-57070 Metz, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 19期
关键词：
Cdc25; phosphatases; Coumarins; Chalcones; Heck coupling; CELL-GROWTH; SPECIFICITY;
D O I：
10.1016/j.bmcl.2010.07.130
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The cell division cycle 25 (Cdc25) family of proteins are dual specificity phosphatases that activate cyclin-dependent kinase (CDK) complexes, which in turn regulate progression through the cell division cycle. Overexpression of Cdc25 proteins has been reported in a wide variety of cancers; their inhibition may thus represent a novel approach for the development of anticancer therapeutics. Herein we report new coumarin-based scaffolds endowed with a selective inhibition against Cdc25A and Cdc25C, being 6a and 6d the most efficient inhibitors and worthy of further investigation as anticancer agents. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5827 / 5830
页数：4
相关论文
共 50 条
  • [31] Novel dual inhibitor targeting CDC25 and HDAC for treating triple-negative breast cancer
    Sethy, Bidyadhar
    Upadhyay, Richa
    Narwanti, Iin
    Yu, Zih-Yao
    Lee, Sung-Bau
    Liou, Jing-Ping
    APOPTOSIS, 2024, 29 (11-12) : 2047 - 2073
  • [32] Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells
    Zwergel, Clemens
    Czepukojc, Brigitte
    Evain-Bana, Emilie
    Xu, Zhanjie
    Stazi, Giulia
    Mod, Mattia
    Patsilinakos, Alexandros
    Mai, Antonello
    Botta, Bruno
    Ragno, Rino
    Bagrel, Denise
    Kirsch, Gilbert
    Meiser, Peter
    Jacob, Claus
    Montenarh, Mathias
    Valente, Sergio
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 134 : 316 - 333
  • [33] Synthesis and evaluation of coumarin/piperazine hybrids as acetylcholinesterase inhibitors
    Zhang, Juan
    Jiang, Cheng-Shi
    MEDICINAL CHEMISTRY RESEARCH, 2018, 27 (06) : 1717 - 1727
  • [34] Design and synthesis of macrocyclic inhibitors of phosphatase Cdc25B
    Bäurle, S
    Blume, T
    Günther, J
    Henschel, D
    Hillig, RC
    Husemann, M
    Mengel, A
    Parchmann, C
    Schmid, E
    Skuballa, W
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (07) : 1673 - 1677
  • [35] New coumarin-based fluorescent melatonin ligands. Design, synthesis and pharmacological characterization
    de la Fuente Revenga, Mario
    Herrera-Arozamena, Clara
    Fernandez-Saez, Nerea
    Barco, Gema
    Garcia-Orue, Itxaso
    Sugden, David
    Rivara, Silvia
    Isabel Rodriguez-Franco, Maria
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 103 : 370 - 373
  • [36] Synthesis and biological evaluation of coumarin based isoxazoles, pyrimidinthiones and pyrimidin-2-ones
    Patel, Divyesh
    Kumari, Premlata
    Patel, Navin B.
    ARABIAN JOURNAL OF CHEMISTRY, 2017, 10 : S3990 - S4001
  • [37] Design, synthesis and biological evaluation of coumarin-3-carboxamides as selective carbonic anhydrase IX and XII inhibitors
    Thacker, Pavitra S.
    Alvala, Mallika
    Arifuddin, Mohammed
    Angeli, Andrea
    Supuran, Claudiu T.
    BIOORGANIC CHEMISTRY, 2019, 86 : 386 - 392
  • [38] Synthesis of novel anticancer coumarin-triazole-chalcone hybrids as potential AKT inhibitors
    Mallikarjun, E.
    Suneesha, D.
    Kumar, A. Niranjana
    Singh, Akanksha
    Dutta, Hashnu
    Kumar, J. Kotesh
    Srinivas, K. V. N. Satya
    Meena, Abha
    Venkatesh, B.
    Jain, Nishant
    Radhika, T.
    Sravanthi
    INDIAN JOURNAL OF CHEMISTRY, 2023, 62 (11): : 1162 - 1170
  • [39] Synthesis and biological evaluation of novel coumarin-pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents
    Amin, Kamilia M.
    Eissa, Amal A. M.
    Abou-Seri, Sahar M.
    Awadallah, Fadi M.
    Hassan, Ghaneya S.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 60 : 187 - 198
  • [40] Design, Synthesis, and Biological Evaluation of Novel Allosteric Protein Disulfide Isomerase Inhibitors
    Yang, Suhui
    Shergalis, Andrea
    Lu, Dan
    Kyani, Anahita
    Liu, Ziwei
    Ljungman, Mats
    Neamati, Nouri
    JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (07) : 3447 - 3474
12345