Cardiac remodelling - Part 2: Clinical, imaging and laboratory findings. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology

被引：26

作者：

Aimo, Alberto ^{[1
,2
]}

Vergaro, Giuseppe ^{[1
,2
]}

Gonzalez, Arantxa ^{[3
,4
,5
]}

Barison, Andrea ^{[1
,2
]}

Lupon, Josep ^{[6
]}

Delgado, Victoria ^{[6
]}

Richards, A. Mark ^{[7
]}

de Boer, Rudolf A. ^{[8
]}

Thum, Thomas ^{[9
,10
]}

Arfsten, Henrike ^{[9
,10
]}

Hulsmann, Martin ^{[9
]}

Falcao-Pires, Ines ^{[11
]}

Diez, Javier ^{[12
]}

Foo, Roger S. Y. ^{[13
]}

Chan, Mark Yan Yee ^{[13
]}

Anene-Nzelu, Chukwuemeka G. ^{[13
]}

Abdelhamid, Magdy ^{[14
]}

Adamopoulos, Stamatis ^{[15
]}

Anker, Stefan D. ^{[16
,17
]}

Belenkov, Yuri ^{[18
]}

Gal, Tuvia B. ^{[19
]}

Cohen-Solal, Alain ^{[20
]}

Bohm, Michael ^{[21
]}

Chioncel, Ovidiu ^{[22
]}

Jankowska, Ewa A. ^{[23
]}

Gustafsson, Finn ^{[24
]}

Hill, Loreena ^{[25
]}

Jaarsma, Tiny ^{[26
]}

Januzzi, James L. ^{[27
,28
]}

Jhund, Pardeep ^{[29
]}

Lopatin, Yuri ^{[30
]}

Lund, Lars H. ^{[31
,32
]}

Metra, Marco ^{[33
]}

Milicic, Davor ^{[34
]}

Moura, Brenda ^{[11
,35
]}

Mueller, Christian ^{[36
]}

Mullens, Wilfried ^{[37
]}

Nunez, Julio ^{[38
]}

Piepoli, Massimo F. ^{[39
]}

Rakisheva, Amina ^{[40
]}

Ristic, Arsen D. ^{[41
,42
]}

Rossignol, Patrick ^{[43
,44
]}

Savarese, Gianluigi ^{[31
,32
]}

Tocchetti, Carlo G. ^{[45
]}

van Linthout, Sophie ^{[46
,47
]}

Volterrani, Maurizio ^{[48
]}

Seferovic, Petar ^{[42
,49
]}

Rosano, Giuseppe ^{[50
]}

Coats, Andrew J. S. ^{[51
]}

Emdin, Michele ^{[1
,2
]}

机构：

[1] Scuola Super Sant Anna, Pisa, Italy

[2] Fdn Toscana Gabriele Monasterio, Div Cardiol, Pisa, Italy

[3] Univ Navarra, CIMA, Pamplona, Spain

[4] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain

[5] Carlos III Inst Hlth, CIBERCV, Madrid, Spain

[6] Hosp Badalona Germans Trias & Pujol, Inst Cor, Barcelona, Spain

[7] Univ Otago, Dunedin, New Zealand

[8] Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands

[9] Med Univ Vienna, Dept Internal Med 2, Clin Div Cardiol, Vienna, Austria

[10] German Ctr Cardiovasc Res DZHK, Partner Site Berlin, Berlin, Germany

[11] Univ Porto, Fac Med, Porto, Portugal

[12] Ctr Appl Med Res, Pamplona, Spain

[13] Natl Univ Singapore Hosp, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore

[14] Cairo Univ, Fac Med, Cairo, Egypt

[15] Onassis Cardiac Surg Ctr, Dept Cardiovasc Med 2, Athens, Greece

[16] Charite, Dept Cardiol CVK, Berlin, Germany

[17] Charite, Berlin Inst Hlth, Ctr Regenerat Therapy BCRT, German Ctr Cardiovasc Res DZHK, Partner Site Berlin, Berlin, Germany

[18] Lomonosv Moscow State Univ, Moscow, Russia

[19] Rabin Med Ctr, Dept Cardiol, Beilinson, Israel

[20] Hosp Lariboisiere, Paris, France

[21] Univ Saarland, Homburg, Germany

[22] Univ Med & Pharm Carol Davila, Emergency Inst Cardiovasc Dis Prof CC Iliescu Buc, Bucharest, Romania

[23] Wroclaw Med Univ, Inst Heart Dis, Wroclaw, Poland

[24] Copenhagen Univ Hosp, Rigshosp, Dept Cardiol, Heart Ctr, Copenhagen, Denmark

[25] Queens Univ Belfast, Belfast, Antrim, North Ireland

[26] Linkoping Univ, Linkoping, Sweden

[27] Massachusetts Gen Hosp, Boston, MA 02114 USA

[28] Baim Inst Clin Res, Boston, MA USA

[29] Univ Glasgow, Glasgow, Lanark, Scotland

[30] Volgograd State Med Univ, Volgograd, Russia

[31] Karolinska Inst, Dept Med, Stockholm, Sweden

[32] Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden

[33] Univ Brescia, Dept Med & Surg Specialties, Radiol Sci & Publ Hlth, ASST Spedali Civili,Cardiol, Brescia, Italy

[34] Univ Zagreb, Sch Med, Zagreb, Croatia

[35] Porto Armed Forces Hosp, Dept Cardiol, Porto, Portugal

[36] Univ Hosp, Dept Cardiol, Basel, Switzerland

[37] Hosp Oost Limburg, Genk, Belgium

[38] Univ Valencia, INCLIVA, Hosp Clin Univ Valencia, Valencia, Spain

[39] Castelsangiovanni Hosp, Div Cardiol, Castelsangiovanni, Italy

[40] Sci Res Inst Cardiol & Internal Med, Alma Ata, Kazakhstan

[41] Univ Clin Ctr Serbia, Dept Cardiol, Belgrade, Serbia

[42] Univ Belgrade, Fac Med, Belgrade, Serbia

[43] Univ Lorraine, Ctr Invest Clin Plurithemat 1433, Nancy, France

[44] CHRU Nancy, INSERM, U1116, F CRIN INI CRCT, Nancy, France

[45] Univ Naples Federico II, Ctr Basic & Clin Immunol Res CISI, Interdept Ctr Clin & Translat Sci CIRCET,Cardioon, Interdept Hypertens Res Ctr CIRIAPA,Dept Translat, Naples, Italy

[46] Charite Univ Med Berlin, Berlin Inst Hlth BIH, BIH Ctr Regenerat Therapies BCRT, Berlin, Germany

[47] German Ctr Cardiovasc Res DZHK, Partner Site Berlin, Berlin, Germany

[48] IRCCS San Raffaele, Rome, Italy

[49] Serbian Acad Arts & Sci, Belgrade, Serbia

[50] Univ London, St Georges Hosp, NHS Trust, London, England

来源：

EUROPEAN JOURNAL OF HEART FAILURE | 2022年 / 24卷 / 06期

关键词：

Heart failure; Ejection fraction; Remodelling; Predictors; Imaging; Biomarkers; Therapies; VENTRICULAR EJECTION FRACTION; DILATED CARDIOMYOPATHY INSIGHTS; CARDIOVASCULAR MAGNETIC-RESONANCE; CONVERTING-ENZYME-INHIBITORS; LATE GADOLINIUM ENHANCEMENT; AORTIC-VALVE-REPLACEMENT; RESYNCHRONIZATION THERAPY; MYOCARDIAL-INFARCTION; PROGNOSTIC-SIGNIFICANCE; TROPONIN-T;

D O I：

10.1002/ejhf.2522

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In patients with heart failure, the beneficial effects of drug and device therapies counteract to some extent ongoing cardiac damage. According to the net balance between these two factors, cardiac geometry and function may improve (reverse remodelling, RR) and even completely normalize (remission), or vice versa progressively deteriorate (adverse remodelling, AR). RR or remission predict a better prognosis, while AR has been associated with worsening clinical status and outcomes. The remodelling process ultimately involves all cardiac chambers, but has been traditionally evaluated in terms of left ventricular volumes and ejection fraction. This is the second part of a review paper by the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology dedicated to ventricular remodelling. This document examines the proposed criteria to diagnose RR and AR, their prevalence and prognostic value, and the variables predicting remodelling in patients managed according to current guidelines. Much attention will be devoted to RR in patients with heart failure with reduced ejection fraction because most studies on cardiac remodelling focused on this setting.

引用

页码：944 / 958

页数：15

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