Complete resolution of laryngeal amyloidosis with radiation treatment

被引:25
作者
Neuner, Geoffrey A. [1 ]
Badros, Ashraf A. [2 ]
Meyer, Tanya K. [4 ]
Nanaji, Nahid M. [3 ]
Regine, William F. [1 ]
机构
[1] Univ Maryland, Med Ctr, Dept Radiat Oncol, Baltimore, MD 21201 USA
[2] Univ Maryland, Med Ctr, Dept Hematol & Oncol, Baltimore, MD 21201 USA
[3] Univ Maryland, Med Ctr, Dept Pathol, Baltimore, MD 21201 USA
[4] Univ Washington, Dept Otolaryngol, Seattle, WA 98195 USA
来源
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2012年 / 34卷 / 05期
关键词
amyloidosis; larynx; localized; radiation; plasmacytoma; SOLITARY EXTRAMEDULLARY PLASMACYTOMA; TRACHEOBRONCHIAL AMYLOIDOSIS; LOCALIZED AMYLOIDOSIS; THERAPY; RADIOTHERAPY; MANAGEMENT; TUMOR; NECK; HEAD; TRACHEA;
D O I
10.1002/hed.21626
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background. Localized amyloidosis of the larynx is a rare entity of unclear etiology. Surgical debulking is the primary treatment modality but often is not curative. Methods and Results. A 41-year-old woman presenting with increasing hoarseness, dysphagia, dyspnea, and weight loss was found to have a submucosal mass in the left false vocal fold. Biopsy of the specimen revealed amyloid. After negative work-up for systemic disease, the patient underwent surgical debulking. Specimens revealed a population of clonal plasma cells demonstrating lambda restriction. The patient was treated with adjuvant external beam radiation to a dose of 45 Gy. At 11 months, the patient's voice, breathing, and swallowing have all improved substantially. Conclusions. Recent pathologic studies suggest that localized amyloidosis of the larynx is caused by a localized, nonmalignant plasma cell disorder. Because full resection is difficult, we recommend a combination of surgery and radiation therapy to cure this disease. (C) 2010 Wiley Periodicals, Inc. Head Neck 34: 748-752, 2012
引用
收藏
页码:748 / 752
页数:5
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