Design, synthesis and evaluation of novel (S)-tryptamine derivatives containing an allyl group and an aryl sulfonamide unit as anticancer agents

被引：23

作者：

Guo, Zhenbo ^{[1
]}

Xu, Yiming ^{[1
]}

Peng, Yujie ^{[2
]}

Rashid, Haroon Ur ^{[1
,3
]}

Quan, Wei ^{[1
]}

Xie, Peng ^{[1
]}

Wu, Lichuan ^{[2
]}

Jiang, Jun ^{[1
]}

Wang, Lisheng ^{[2
]}

Liu, Xu ^{[2
]}

机构：

[1] Guangxi Univ, Sch Chem & Chem Engn, Nanning 530004, Guangxi, Peoples R China

[2] Guangxi Univ, Med Coll, Nanning 530004, Guangxi, Peoples R China

[3] Sarhad Univ Sci & Informat Technol, Dept Chem, Peshawar, KP, Pakistan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2019年 / 29卷 / 09期

关键词：

Tryptamine; Aryl sulfonamide; Cell cycle arrest; Anticancer; 5-HT1D RECEPTOR; INHIBITORS; REDUCTION; DISCOVERY;

D O I：

10.1016/j.bmcl.2019.02.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of (S)-tryptamine derivatives containing an allyl group and an aryl sulfonamide unit were designed, synthesized and evaluated for their potential application as anticancer agents. The structures of the synthesized compounds were characterized by 1H NMR, C-13 NMR and ESI-MS spectral analyses. The target compounds were evaluated for their in vitro cytotoxicity against HepG2, HeLa, CNE1 and A549 human cancer cell lines. Some of the synthesized compounds showed moderate to good anticancer activities against four selected cancer cell lines, among of which 6ag was found to be the most active analogue possessing IC50 values 16.5-18.7 mu M. Further mechanism studies revealed that compound 6ag could significantly induce HepG2 cell cycle arrest at G1 phase, promote cell apoptosis, and inhibit the colony formation as well.

引用

页码：1133 / 1137

页数：5

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