Multiresidue analysis of tranquilizers and the beta-blocker Carazolol in meat by liquid chromatography/tandem mass spectrometry

被引：17

作者：

Kaufmann, A ^{[1
]}

Ryser, B ^{[1
]}

机构：

[1] Official Food Control Author Canton Zurich, Kantonales Lab Zurich, CH-8030 Zurich, Switzerland

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2001年 / 15卷 / 18期

关键词：

D O I：

10.1002/rcm.393

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A fast and simple method for the quantification of a number of tranquilizers and the beta-blocker Carazolol in pork and bovine kidney is described. Extracts are purified/concentrated by a solid phase extraction step and separated on a reversed phase column with an alkaline (ammonia) acetonitrile gradient. The electrospray tandem mass spectrometer is operated in positive ion multireaction monitoring mode. Resulting chromatograms are free of interfering peaks. The recovery is >75% for all analytes and the limit of detection <1 ppb, which is well below the current maximum residue limit for the various compounds. Copyright (C) 2001 John Wiley & Sons, Ltd.

引用

页码：1747 / 1751

页数：5

共 13 条

[1] A METHOD FOR THE ANALYSIS OF SOME NEUROLEPTICS AND CARAZOLOL IN PORK KIDNEYS [J].

ARNETH, W .

ZEITSCHRIFT FUR LEBENSMITTEL-UNTERSUCHUNG UND-FORSCHUNG, 1995, 201 (03) :261-265

[2]

BATJOENS P, 2000, EURORESIDUE, V4, P208

[3] INVESTIGATION OF THE METABOLISM OF AZAPERONE IN THE HORSE [J].

CHUI, YC ;

ESAW, B ;

LAVIOLETTE, B .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1994, 652 (01) :23-33

[4]

DUBOIS M, 2000, EURORESIDUE, V4, P398

[5]

ETTER R, 1984, Mitteilungen aus dem Gebiete der Lebensmitteluntersuchung und Hygiene, V75, P447

[6] Multi-residue analysis of tranquillizers in meat: confirmatory assays using mass spectrometry [J].

Govaert, Y ;

Batjoens, P ;

Tsilikas, K ;

Degroodt, JM ;

Srebrnik, S .

ANALYST, 1998, 123 (12) :2507-2512

[7]

HOLLAND DC, 1993, J AOAC INT, V76, P720

[8]

HOOGLAND H, 1991, ARCH LEBENSMITTELHYG, V42, P77

[9]

KEUKENS HJ, 1989, J CHROMATOGR, V464, P149

[10]

MACHO M, 1993, EURORESIDUE, V2, P465

← 1 2 →