IgM in the kidney: a multiple personality disorder

被引：22

作者：

Platt, Jeffrey L. ^{[1
,2
]}

Cascalho, Manila ^{[1
,2
]}

机构：

[1] Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA

来源：

KIDNEY INTERNATIONAL | 2015年 / 88卷 / 03期

关键词：

REPERFUSION INJURY; ANTIBODIES;

D O I：

10.1038/ki.2015.153

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

IgM in the blood of normal individuals consists mainly of 'natural' polyreactive antibodies. Natural IgM is thought to provide an initial defense against infection and to promote the healing of wounded cells. Yet, as Panzer and colleagues show, these benefits can be eclipsed when the IgM binds to damaged cells of the glomerulus, activating complement. IgM in glomeruli thus signifies cellular damage and may warn that the pace of that damage exceeds the capacity for repair.

引用

页码：439 / 441

页数：3

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