Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases

被引：21

作者：

Kobayashi, Tsutomu ^{[1
]}

Ito, Takashi ^{[1
]}

Shiomi, Masashi ^{[1
,2
]}

机构：

[1] Kobe Univ, Grad Sch Med, Inst Expt Anim, Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] Kobe Univ, Grad Sch Med, Div Cardiovasc Med, Sect Anim Models Cardiovasc Dis,Chuo Ku, Kobe, Hyogo 6500017, Japan

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2011年

关键词：

LOW-DENSITY-LIPOPROTEIN; COENZYME-A REDUCTASE; HERITABLE HYPERLIPIDEMIC RABBITS; NITRIC-OXIDE BIOAVAILABILITY; COLONY-STIMULATING FACTOR; VERY-LOW-DENSITY; ANIMAL-MODEL; PRAVASTATIN SODIUM; CORONARY ATHEROSCLEROSIS; MYOCARDIAL-INFARCTION;

D O I：

10.1155/2011/406473

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Conquering cardiovascular diseases is one of the most important problems in human health. To overcome cardiovascular diseases, animal models have played important roles. Although the prevalence of genetically modified animals, particularly mice and rats, has contributed greatly to biomedical research, not all human diseases can be investigated in this way. In the study of cardiovascular diseases, mice and rats are inappropriate because of marked differences in lipoprotein metabolism, pathophysiological findings of atherosclerosis, and cardiac function. On the other hand, since lipoprotein metabolism and atherosclerotic lesions in rabbits closely resemble those in humans, several useful animal models for these diseases have been developed in rabbits. One of the most famous of these is the Watanabe heritable hyperlipidemic (WHHL) rabbit, which develops hypercholesterolemia and atherosclerosis spontaneously due to genetic and functional deficiencies of the low-density lipoprotein (LDL) receptor. The WHHL rabbit has been improved to develop myocardial infarction, and the new strain was designated the myocardial infarction-prone WHHL (WHHLMI) rabbit. This review summarizes the importance of selecting animal species for translational research in biomedical science, the development of WHHL and WHHLMI rabbits, their application to the development of hypocholesterolemic and/or antiatherosclerotic drugs, and future prospects regarding WHHL and WHHLMI rabbits.

引用

页数：10

共 79 条

[21] PROBUCOL PREVENTS THE PROGRESSION OF ATHEROSCLEROSIS IN WATANABE HERITABLE HYPERLIPIDEMIC RABBIT, AN ANIMAL-MODEL FOR FAMILIAL HYPERCHOLESTEROLEMIA [J].

KITA, T ;

NAGANO, Y ;

YOKODE, M ;

ISHII, K ;

KUME, N ;

OOSHIMA, A ;

YOSHIDA, H ;

KAWAI, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (16) :5928-5931

[22] DELAYED CLEARANCE OF VERY LOW-DENSITY AND INTERMEDIATE DENSITY LIPOPROTEINS WITH ENHANCED CONVERSION TO LOW-DENSITY LIPOPROTEIN IN WHHL RABBITS [J].

KITA, T ;

BROWN, MS ;

BILHEIMER, DW ;

GOLDSTEIN, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (18) :5693-5697

[23] HEPATIC-UPTAKE OF CHYLOMICRON REMNANTS IN WHHL RABBITS - A MECHANISM GENETICALLY DISTINCT FROM THE LOW-DENSITY LIPOPROTEIN RECEPTOR [J].

KITA, T ;

GOLDSTEIN, JL ;

BROWN, MS ;

WATANABE, Y ;

HORNICK, CA ;

HAVEL, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (11) :3623-3627

[24]

Koike H, 2001, AM J CARDIOL, V87, p33C

[25] Hepatic expression of the catalytic subunit of the apolipoprotein B mRNA editing enzyme (apobec-1) ameliorates hypercholesterolemia in LDL receptor-deficient rabbits [J].

Kozarsky, KF ;

Bonen, DK ;

Giannoni, F ;

Funahashi, T ;

Wilson, JM ;

Davidson, NO .

HUMAN GENE THERAPY, 1996, 7 (08) :943-957

[26] EFFECTS OF PRAVASTATIN SODIUM ALONE AND IN COMBINATION WITH CHOLESTYRAMINE ON HEPATIC, INTESTINAL AND ADRENAL LOW-DENSITY-LIPOPROTEIN RECEPTORS IN HOMOZYGOUS WATANABE HERITABLE HYPERLIPIDEMIC RABBITS [J].

KURODA, M ;

MATSUMOTO, A ;

ITAKURA, H ;

WATANABE, Y ;

ITO, T ;

SHIOMI, M ;

FUKUSHIGE, J ;

NARA, F ;

FUKAMI, M ;

TSUJITA, Y .

JAPANESE JOURNAL OF PHARMACOLOGY, 1992, 59 (01) :65-70

[27] EFFECT OF FISH OIL ON ATHEROGENESIS IN WATANABE HERITABLE HYPERLIPIDEMIC RABBIT [J].

LICHTENSTEIN, AH ;

CHOBANIAN, AV .

ARTERIOSCLEROSIS, 1990, 10 (04) :597-606

[28] Intensive Statin Therapy in Acute Coronary Syndromes [J].

Liew, Tze Vun ;

Ray, Kausik K. .

CURRENT ATHEROSCLEROSIS REPORTS, 2008, 10 (02) :158-163

[29] In vivo temporal and spatial distribution of depolarization and repolarization and the illusive murine T wave [J].

Liu, G ;

Iden, JB ;

Kovithavongs, K ;

Gulamhusein, R ;

Duff, HJ ;

Kavanagh, KM .

JOURNAL OF PHYSIOLOGY-LONDON, 2004, 555 (01) :267-279

[30] Cardiac arrhythmias: From (transgenic) mice to men [J].

London, B .

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2001, 12 (09) :1089-1091

← 1 2 3 4 5 6 7 8 →