Regulation of CD44 expression by tumor necrosis factor-α and its potential role in breast cancer cell migration

被引：22
作者：
Li, Jun [1 ]
Zha, Xiao-Ming [3 ]
Wang, Rong [1 ]
Li, Xiao-Dong [1 ,2 ]
Xu, Bei [1 ]
Xu, Yan-Jie [1 ]
Yin, Yong-Mei [1 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Med Oncol, Nanjing 210029, Jiangsu, Peoples R China
[2] Soochow Univ, Affiliated Hosp 3, Dept Oncol, Changzhou, Peoples R China
[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Breast Surg, Nanjing 210029, Jiangsu, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2012年 / 66卷 / 02期
关键词：
Breast cancer; TNF-alpha; CD44; Migration; MAPK; COLORECTAL-CANCER; SPLICE VARIANTS; MAPK PATHWAY; CARCINOMA; PROGRESSION; METASTASIS; INVASION; ACTIVATION; CYTOKINES; RECEPTOR;
D O I：
10.1016/j.biopha.2011.11.021
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
CD44 molecule plays critical role in distant malignant metastasis. It is expressed in standard form (CD44s) or variant form (CD44v). Tumor necrosis factor-alpha (TNF-alpha) is highly expressed in the cancer microenvironment. TNF-alpha was reported to modulate CD44 expression in several kinds of cancer. However, little is known about pathological role of TNF-alpha in breast cancer (BC) cells. In the current investigation, we investigated the effect of TNF-alpha on BC cells (MCF-7 and MDA-MB-231) viability, CD44 expression, and in vitro migration. We found that TNF-alpha down-regulated CD44s expression, up-regulated CD44v3 and CD44v6 expression through JNK pathway in MCF-7 cells. In MDA-MB-231 cells, TNF-alpha up-regulated CD44s, CD44v3 and CD44v6 expression via p38 pathway. These data indicate important role of CD44 molecule in BC pathology. (c) 2012 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：144 / 150
页数：7
相关论文
共 50 条
  • [41] Transcriptional elucidation of tumor necrosis factor-α-mediated nuclear factor-κB1 activation in breast cancer cohort of Pakistan
    Qadir, Javeria
    Riaz, Syeda Kiran
    Sahar, Namood-e
    Aman, Durkhshan
    Khan, Muhammad Jawad
    Malik, Muhammad Faraz Arshad
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2020, 16 (06) : 1443 - 1448
  • [42] Influence of Hyaluronan Density on the Behavior of Breast Cancer Cells with Different CD44 Expression
    Carvalho, Ana M.
    da Costa, Diana Soares
    Reis, Rui L.
    Pashkuleva, Iva
    ADVANCED HEALTHCARE MATERIALS, 2022, 11 (04)
  • [43] CD44 variant expression and estrogen receptor status in breast cancer
    A. Kate Hole
    Abbes Belkhiri
    Linda S. Snell
    Peter H. Watson
    Breast Cancer Research and Treatment, 1997, 43 : 165 - 173
  • [44] A Novel Gemini Vitamin D Analog Represses the Expression of a Stem Cell Marker CD44 in Breast Cancer
    So, Jae Young
    Lee, Hong Jin
    Smolarek, Amanda K.
    Paul, Shiby
    Wang, Chung-Xiou
    Maehr, Hubert
    Uskokovic, Milan
    Zheng, Xi
    Conney, Allan H.
    Cai, Li
    Liu, Fang
    Suh, Nanjoo
    MOLECULAR PHARMACOLOGY, 2011, 79 (03) : 360 - 367
  • [45] CD44 variant expression and estrogen receptor status in breast cancer
    Hole, AK
    Belkhiri, A
    Snell, LS
    Watson, PH
    BREAST CANCER RESEARCH AND TREATMENT, 1997, 43 (02) : 165 - 173
  • [46] Enhanced membrane-type 1 matrix metalloproteinase expression by hyaluronan oligosaccharides in breast cancer cells facilitates CD44 cleavage and tumor cell migration
    Kung, Chang-I
    Chen, Cheng-Yi
    Yang, Chih-Chang
    Lin, Cheng-Yu
    Chen, Tien-Hua
    Wang, Hwai-Shi
    ONCOLOGY REPORTS, 2012, 28 (05) : 1808 - 1814
  • [47] Splice variant expression of CD44 in patients with breast and ovarian cancer
    Lockhart, MS
    Hajos, SE
    Basilio, FM
    Mongini, C
    Alvarez, E
    ONCOLOGY REPORTS, 2001, 8 (01) : 145 - 151
  • [48] Involvement of tumor necrosis factor-α in the upregulation of CXCR4 expression in gastric cancer induced by Helicobacter pylori
    Zhao, Chenghai
    Lu, Xiaomei
    Bu, Xianmin
    Zhang, Ning
    Wang, Wei
    BMC CANCER, 2010, 10
  • [49] An Immunohistochemical Study of Breast Cancer Brain Metastases: The Role of CD44 and AKT in the Prognosis
    Gama, Joao Martins
    Oliveira, Rui Caetano
    Teixeira, Paulo
    Silva, Fatima
    Abrantes, Carlos
    Figueiredo, Paulo
    Simoes, Sandra
    Rebelo, Olinda
    Cipriano, Maria Augusta
    APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2023, 31 (05) : 318 - 323
  • [50] Circulating tumor cells expressing cancer stem cell marker CD44 as a diagnostic biomarker in patients with gastric cancer
    Watanabe, Toru
    Okumura, Tomoyuki
    Hirano, Katsuhisa
    Yamaguchi, Tetsuji
    Sekine, Shinichi
    Nagata, Takuya
    Tsukada, Kazuhiro
    ONCOLOGY LETTERS, 2017, 13 (01) : 281 - 288
12345