Regulation of CD44 expression by tumor necrosis factor-α and its potential role in breast cancer cell migration

被引：22
作者：
Li, Jun [1 ]
Zha, Xiao-Ming [3 ]
Wang, Rong [1 ]
Li, Xiao-Dong [1 ,2 ]
Xu, Bei [1 ]
Xu, Yan-Jie [1 ]
Yin, Yong-Mei [1 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Med Oncol, Nanjing 210029, Jiangsu, Peoples R China
[2] Soochow Univ, Affiliated Hosp 3, Dept Oncol, Changzhou, Peoples R China
[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Breast Surg, Nanjing 210029, Jiangsu, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2012年 / 66卷 / 02期
关键词：
Breast cancer; TNF-alpha; CD44; Migration; MAPK; COLORECTAL-CANCER; SPLICE VARIANTS; MAPK PATHWAY; CARCINOMA; PROGRESSION; METASTASIS; INVASION; ACTIVATION; CYTOKINES; RECEPTOR;
D O I：
10.1016/j.biopha.2011.11.021
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
CD44 molecule plays critical role in distant malignant metastasis. It is expressed in standard form (CD44s) or variant form (CD44v). Tumor necrosis factor-alpha (TNF-alpha) is highly expressed in the cancer microenvironment. TNF-alpha was reported to modulate CD44 expression in several kinds of cancer. However, little is known about pathological role of TNF-alpha in breast cancer (BC) cells. In the current investigation, we investigated the effect of TNF-alpha on BC cells (MCF-7 and MDA-MB-231) viability, CD44 expression, and in vitro migration. We found that TNF-alpha down-regulated CD44s expression, up-regulated CD44v3 and CD44v6 expression through JNK pathway in MCF-7 cells. In MDA-MB-231 cells, TNF-alpha up-regulated CD44s, CD44v3 and CD44v6 expression via p38 pathway. These data indicate important role of CD44 molecule in BC pathology. (c) 2012 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：144 / 150
页数：7
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