Symmetric dimers of ent-kaurane diterpenoids with cytotoxic activity from Croton tonkinensis

被引：19

作者：

Phuong Thien Thuong ^{[2
]}

Thi Hong Minh Pham ^{[3
]}

Thi Van Thu Le ^{[1
]}

Trong Tuan Dao ^{[1
]}

Thai Trung Dang ^{[1
]}

Quyet Tien Nguyen ^{[3
]}

Oh, Won Keun ^{[1
]}

机构：

[1] Chosun Univ, Coll Pharm, Project Team BK21, Kwangju 501759, South Korea

[2] Vietnam Natl Inst Med Mat, Hanoi, Vietnam

[3] Vietnam Acad Sci & Technol, Inst Chem, Hanoi, Vietnam

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 02期

关键词：

Croton tonkinensis; Euphorbiaceae; ent-Kaurane diterpenoid; Symmetric dimer; Cytotoxic activity; Breast cancer cell lines; CANCER;

D O I：

10.1016/j.bmcl.2011.11.116

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Breast cancer is the most common malignant tumor in women these days accounting for approximately 24% of all cancer. During our screening program searching for cytotoxic materials from natural products, two new symmetric dimers of ent-kaurane diterpenoid, crotonkinensins C (1) and 0(2), with connectivity at C-17 were isolated from the leaves of the Vietnamese endemic medicinal plant Croton tonkinensis. Their structures were determined on the basis of physicochemical and spectroscopic data. Compound 2 showed a potent cytotoxic activity against MCF-7, tamoxifen-resistant MCF-7 (MCF-7/TAMR), adriamycin-resistant MCF-7 (MCF-7/ADR), and MDA-MB-231 breast cancer cell lines. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1122 / 1124

页数：3

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