Symmetric dimers of ent-kaurane diterpenoids with cytotoxic activity from Croton tonkinensis

被引:18
作者
Phuong Thien Thuong [2 ]
Thi Hong Minh Pham [3 ]
Thi Van Thu Le [1 ]
Trong Tuan Dao [1 ]
Thai Trung Dang [1 ]
Quyet Tien Nguyen [3 ]
Oh, Won Keun [1 ]
机构
[1] Chosun Univ, Coll Pharm, Project Team BK21, Kwangju 501759, South Korea
[2] Vietnam Natl Inst Med Mat, Hanoi, Vietnam
[3] Vietnam Acad Sci & Technol, Inst Chem, Hanoi, Vietnam
关键词
Croton tonkinensis; Euphorbiaceae; ent-Kaurane diterpenoid; Symmetric dimer; Cytotoxic activity; Breast cancer cell lines; CANCER;
D O I
10.1016/j.bmcl.2011.11.116
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Breast cancer is the most common malignant tumor in women these days accounting for approximately 24% of all cancer. During our screening program searching for cytotoxic materials from natural products, two new symmetric dimers of ent-kaurane diterpenoid, crotonkinensins C (1) and 0(2), with connectivity at C-17 were isolated from the leaves of the Vietnamese endemic medicinal plant Croton tonkinensis. Their structures were determined on the basis of physicochemical and spectroscopic data. Compound 2 showed a potent cytotoxic activity against MCF-7, tamoxifen-resistant MCF-7 (MCF-7/TAMR), adriamycin-resistant MCF-7 (MCF-7/ADR), and MDA-MB-231 breast cancer cell lines. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1122 / 1124
页数:3
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