New practical synthesis of panomifene. The effect of 2-trifluoromethyl substituent on the stereoselectivity of dehydration of 1,1,2-triarylethanols.

被引:39
作者
Nemeth, G [1 ]
KapillerDezsofi, R [1 ]
Lax, G [1 ]
Simig, G [1 ]
机构
[1] EGIS PHARMACEUT LTD,DIV CHEM RES,H-1475 BUDAPEST,HUNGARY
关键词
D O I
10.1016/0040-4020(96)00763-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Highly stereoselective eliminations were achieved by acid-catalysed dehydration of 1-(4-alkoxy)-3,3,3-trifluoro-1,2-diphenylpropan-1-ols (10, 11, 15). The influence of the trifluoromethyl group on the stereochemistry of the elimination has been discussed. The observed high stereoselectivity has been applied to give a new, practical synthesis of antiestrogenic drug panomifene (1). Copyright (C) 1996 Published by Elsevier Science Ltd
引用
收藏
页码:12821 / 12830
页数:10
相关论文
共 12 条