Antibiotic resistance genes in bacteriophages from diverse marine habitats

被引：44

作者：

Calero-Caceres, William ^{[1
]}

Luis Balcazar, Jose ^{[2
]}

机构：

[1] Univ Tecn Ambato, Fac Ciencias Agr, Ctr Invest Agr, UTA RAM OneHlth Grp, Tungurahua, Ecuador

[2] Univ Girona, Catalan Inst Water Res ICRA, Girona, Spain

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2019年 / 654卷

关键词：

Marine bacteriophages; Environmental reservoirs; Antibiotic resistance genes; ANTIMICROBIAL RESISTANCE; BACTERIAL; PERSISTENCE; ENVIRONMENT; RESERVOIRS; FRACTIONS; PARTICLES; NETWORK; HOST;

D O I：

10.1016/j.scitotenv.2018.11.166

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Although antibiotic resistance represents a significant and growing threat to human and environmental health worldwide, the contribution of bacteriophages (phages) to the acquisition and spread of antibiotic resistance genes (ARGs) in the environment has not been extensively explored. In this study, a comprehensive analysis of several viromes from diverse marine habitats was performed to investigate whether or not phages carry ARGs. The analysis provides strong evidence that phages from marine habitats are potential reservoirs of ARGs. In fact, genes conferring resistance to aminocoumarin, bacitracin and multidrug resistance (particularly the mexB gene) were found in all analyzed marine viromes. Given this, the role of phages as reservoirs of ARGs should not be underestimated considering their global distribution. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：452 / 455

页数：4

共 48 条

[1] Abundance of antibiotic resistance genes in environmental bacteriophages [J].

Anand, Taruna ;

Bera, Bidhan Ch. ;

Vaid, Rajesh K. ;

Barua, Sanjay ;

Riyesh, Thachamvally ;

Virmani, Nitin ;

Hussain, Mubarik ;

Singh, Raj K. ;

Tripathi, Bhupendra N. .

JOURNAL OF GENERAL VIROLOGY, 2016, 97 :3458-3466

[2] DeepARG: a deep learning approach for predicting antibiotic resistance genes from metagenomic data [J].

Arango-Argoty, Gustavo ;

Garner, Emily ;

Prudent, Amy ;

Heath, Lenwood S. ;

Vikesland, Peter ;

Zhang, Liqing .

MICROBIOME, 2018, 6

[3] Temperate bacteriophages as regulators of host behavior [J].

Argov, Tal ;

Azulay, Gil ;

Pasechnek, Anna ;

Stadnyuk, Olga ;

Ran-Sapir, Shai ;

Borovok, Ilya ;

Sigal, Nadejda ;

Herskovits, Anat A. .

CURRENT OPINION IN MICROBIOLOGY, 2017, 38 :81-87

[4] metaxa2: improved identification and taxonomic classification of small and large subunit rRNA in metagenomic data [J].

Bengtsson-Palme, Johan ;

Hartmann, Martin ;

Eriksson, Karl Martin ;

Pal, Chandan ;

Thorell, Kaisa ;

Larsson, Dan Goran Joakim ;

Nilsson, Rolf Henrik .

MOLECULAR ECOLOGY RESOURCES, 2015, 15 (06) :1403-1414

[5] The truth about metagenomics: quantifying and counteracting bias in 16S rRNA studies [J].

Brooks, J. Paul ;

Edwards, David J. ;

Harwich, Michael D., Jr. ;

Rivera, Maria C. ;

Fettweis, Jennifer M. ;

Serrano, Myrna G. ;

Reris, Robert A. ;

Sheth, Nihar U. ;

Huang, Bernice ;

Girerd, Philippe ;

Strauss, Jerome F., III ;

Jefferson, Kimberly K. ;

Buck, Gregory A. .

BMC MICROBIOLOGY, 2015, 15

[6] Transfer of antibiotic-resistance genes via phage-related mobile elements [J].

Brown-Jaque, Maryury ;

Calero-Caceres, William ;

Muniesa, Maite .

PLASMID, 2015, 79 :1-7

[7] Fast and sensitive protein alignment using DIAMOND [J].

Buchfink, Benjamin ;

Xie, Chao ;

Huson, Daniel H. .

NATURE METHODS, 2015, 12 (01) :59-60

[8] The occurrence of antibiotic resistance genes in a Mediterranean river and their persistence in the riverbed sediment [J].

Calero-Caceres, William ;

Mendez, Javier ;

Martin-Diaz, Julia ;

Muniesa, Maite .

ENVIRONMENTAL POLLUTION, 2017, 223 :384-394

[9] Persistence of naturally occurring antibiotic resistance genes in the bacteria and bacteriophage fractions of wastewater [J].

Calero-Caceres, William ;

Muniesa, Maite .

WATER RESEARCH, 2016, 95 :11-18

[10] Sludge As a Potential Important Source of Antibiotic Resistance Genes in Both the Bacterial and Bacteriophage Fractions [J].

Calero-Caceres, William ;

Melgarejo, Ana ;

Colomer-Lluch, Marta ;

Stoll, Claudia ;

Lucena, Francisco ;

Jofre, Juan ;

Muniesa, Maite .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2014, 48 (13) :7602-7611

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