The potential use of mesenchymal stem cells in stroke therapy-From bench to bedside

被引:34
|
作者
Dulamea, Adriana Octaviana [1 ]
机构
[1] UMF Carol Davila, Fundeni Clin Inst, Dept Neurol, 258 Sos Fundeni,Sect 2, Bucharest, Romania
关键词
Mesenchymal stem cells; Stroke; Angiogenesis; Inflammation; Neurogenesis; Clinical trial; MARROW STROMAL CELLS; ENDOTHELIAL GROWTH-FACTOR; FOCAL CEREBRAL-ISCHEMIA; PROMOTE FUNCTIONAL RECOVERY; UMBILICAL-CORD BLOOD; BONE-MARROW; BRAIN-INJURY; MONONUCLEAR-CELLS; ADIPOSE-TISSUE; INTRAARTERIAL DELIVERY;
D O I
10.1016/j.jns.2015.03.014
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Stroke is the second main cause of morbidity and mortality worldwide. The rationale for the use of mesenchymal stem cells (MSCs) in stroke is based on the capacity of MSCs to secrete a large variety of bioactive molecules such as growth factors, cytokines and chemokines leading to reduction of inflammation, increased neurogenesis from the germinative niches of central nervous system, increased angiogenesis, effects on astrocytes, oligodendrocytes and axons. This review presents the data derived from experimental studies and the evidence available from clinical trials about the use of MSCs in stroke therapy. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:1 / 11
页数:11
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