Preparation of functionalized Zn and Mg-organometallics. Application to the performance of diastereoselective cross-couplings

被引：11
作者：
Knochel, Paul [1 ]
Diene, Coura [1 ]
机构：
[1] Univ Munich, Dept Chem, D-81377 Munich, Germany
来源：
COMPTES RENDUS CHIMIE | 2011年 / 14卷 / 09期
关键词：
Zinc; Magnesium; Cross-coupling; Metalation; Palladium; ORGANOZINC REAGENTS; DIRECT INSERTION; ZINC; MAGNESIUM; LICL; PYRIDINES; BASES;
D O I：
10.1016/j.crci.2011.07.002
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This review describes two general approaches for preparing functionalized Zn- and Mg-organometallics. The first method starts from unsaturated halides (X= Cl, Br, I) and involves a direct insertion of Zn or Mg powder in the presence of LiCl. The second method uses aromatic, heterocyclic or olefinic precursors and converts them with LiCl-solubilized bases directly via C-H activation to the corresponding organometallics. (C) 2011 Published by Elsevier Masson SAS on behalf of Academie des sciences.
引用
收藏
页码：842 / 850
页数：9
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