Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development

被引：15

作者：

Cho, Kyoung-Won ^{[1
]}

Cho, Sung-Won ^{[1
]}

Lee, Jong-Min ^{[1
]}

Lee, Min-Jung ^{[1
]}

Gang, Hee-Seok ^{[1
]}

Jung, Han-Sung ^{[1
]}

机构：

[1] Yonsei Univ, Div Anat & Dev Biol,Brain Korea Project 21, Dept Oral Biol,Oral Sci Res Ctr,Yonsei Ctr Biotec, Res Ctr Orofacial Hard Tissue Regenerat,Coll Dent, Seoul 120752, South Korea

来源：

GENE EXPRESSION PATTERNS | 2008年 / 8卷 / 04期

关键词：

pERK; pMEK; pPTEN; pPI3K; tooth; oral development;

D O I：

10.1016/j.gep.2007.12.001

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Investigations into molecular mechanisms in vertebrates have examined which growth factors regulate many of the essential underlying cellular processes in development. Growth factors regulate cell proliferation and differentiation through diverse signaling pathways like the MEK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) pathway. The MEK and ERK pathway can interact with the PI3K (phosphatidylinositol-3-kinase) and PTEN (phosphatase and tensin homologues deleted on chromosome 10) signaling pathway. Interactions between these pathways during development have been extensively studied in many organs; however, the importance of these pathways in oral development is not well known. In this study, we examined the expression of the phosphorylated forms of ERK (pERK), MEK (pMEK), PTEN (pPTEN) and PI3K during mouse development from E13.5 to E16.5. We found unique and overlapping expression of these factors in the cramofacial region, with pERK and pPTEN showing opposing activation patterns in both the tooth and the tongue. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：284 / 290

页数：7

共 10 条

[1] Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires Rac activation of the extracellular signal-regulated kinase pathway [J].