The role of XTRAP-γ in Xenopus pronephros development

被引：12
作者：
Li, DH
Chan, TC
Satow, R
Komazaki, S
Hashizume, K
Asashima, M
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Pediat Surg & Oncol, Tokyo, Japan
[2] Univ Tokyo, ICORP Project, JST, Grad Sch Arts & Sci, Tokyo, Japan
[3] Univ Tokyo, Dept Biol Sci, Tokyo, Japan
[4] Saitama Med Univ, Dept Anat, Omiya, Saitama, Japan
来源：
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 2005年 / 49卷 / 04期
关键词：
XTPAP-y; Xenopus laevis; pronephros; Pax-2; Wnt-4;
D O I：
10.1387/ijdb.052005dl
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We isolated and characterized the Xenopus translocon-associated protein XTRAP-gamma, one of four subunits of the translocon-associated protein complex. TRAP has been proposed to aid the translocation of nascent polypeptides into the lumen of the endoplasmic reticulum, but this has not been demonstrated until now. XTRAP-gamma was specifically expressed in the pronephros tubules of Xenopus laevis from stage 25 during kidney development. Antisense morpholino oligonucleotide-mediated knockdown of XTRAP-gamma suppressed tubulogenesis and decreased expression of the pronephros marker genes Pax-2 and Wnt-4. XTRAP-gamma morpholinos also inhibited differentiation of the pronephros in activin/retinoic acid-treated animal caps. We conclude that XTRAP-gamma plays an important role in the process of pronephros differentiation.
引用
收藏
页码：401 / 408
页数：8
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