What's Nu(SAP) in mitosis and cancer?

被引：47

作者：

Iyer, Jyoti ^{[1
]}

Moghe, Saili ^{[1
]}

Furukawa, Manabu ^{[1
]}

Tsai, Ming-Ying ^{[1
]}

机构：

[1] Univ Nebraska Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198 USA

来源：

CELLULAR SIGNALLING | 2011年 / 23卷 / 06期

关键词：

Microtubule; Importin; Phosphorylation; Aurora B; Polo-like kinase-1; Cell division cycle 2; CELL-CYCLE REGULATION; GENE-EXPRESSION; MITOTIC SPINDLE; IN-VIVO; NF-Y; NUSAP; KINASE; POLO; BOX; PHOSPHORYLATION;

D O I：

10.1016/j.cellsig.2010.11.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Unperturbed mitosis is a prerequisite for the generation of two genetically identical daughter cells. Nucleolar-spindle associated protein (NuSAP) is an important mitotic regulator. The activity of NuSAP is essential for a variety of cellular events that occur during mitosis starting from spindle assembly to cytokinesis. In addition to playing crucial roles during mitosis, NuSAP has been in the spotlight recently due to different studies exhibiting its importance in embryogenesis and cancer. In this review, we have extensively mined the current literature and made connections between different studies involving NuSAP. Importantly, we have assembled data pertaining to NuSAP from several proteomic studies and analyzed it thoroughly. Our review focuses on the role of NuSAP in mitosis and cancer, and brings to light several unanswered questions regarding the regulation of NuSAP in mitosis and its role in carcinogenesis. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：991 / 998

页数：8

共 43 条

[1] SAP - a putative DNA-binding motif involved in chromosomal organization [J].

Aravind, L ;

Koonin, EV .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (03) :112-114

[2] Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival [J].

Bogunovic, Dusan ;

O'Neill, David W. ;

Belitskaya-Levy, Ilana ;

Vacic, Vladimir ;

Yu, Yi-Lo ;

Adams, Sylvia ;

Darvishian, Farbod ;

Berman, Russell ;

Shapiro, Richard ;

Pavlick, Anna C. ;

Lonardi, Stefano ;

Zavadil, Jiri ;

Osman, Iman ;

Bhardwaj, Nina .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (48) :20429-20434

[3] Initial leukemic gene expression profiles of patients with poor in vivo prednisone response are similar to those of blasts persisting under prednisone treatment in childhood acute lymphoblastic leukemia [J].

Cario, Gunnar ;

Fetz, Andrea ;

Bretscher, Christian ;

Moericke, Anja ;

Schrauder, Andre ;

Stanulla, Martin ;

Schrappe, Martin .

ANNALS OF HEMATOLOGY, 2008, 87 (09) :709-716

[4] Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue [J].

Chen, Dung-Tsa ;

Nasir, Aejaz ;

Culhane, Aedin ;

Venkataramu, Chinnambally ;

Fulp, William ;

Rubio, Renee ;

Wang, Tao ;

Agrawal, Deepak ;

McCarthy, Susan M. ;

Gruidl, Mike ;

Bloom, Gregory ;

Anderson, Tove ;

White, Joe ;

Quackenbush, John ;

Yeatman, Timothy .

BREAST CANCER RESEARCH AND TREATMENT, 2010, 119 (02) :335-346

[5] A quantitative atlas of mitotic phosphorylation [J].

Dephoure, Noah ;

Zhou, Chunshui ;

Villen, Judit ;

Beausoleil, Sean A. ;

Bakalarski, Corey E. ;

Elledge, Stephen J. ;

Gygi, Steven P. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (31) :10762-10767

[6] Differential gene expression profiling between wild-type and ALAS2-null erythroblasts: Identification of novel heme-regulated genes [J].

Fujiwara, T ;

Harigae, H ;

Takahashi, S ;

Furuyama, K ;

Nakajima, O ;

Sun, JY ;

Igarashi, K ;

Yamamoto, M ;

Sassa, S ;

Kaku, M ;

Sasaki, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 340 (01) :105-110

[7] Expression analyses and transcriptional regulation of mouse nucleolar spindle-associated protein gene in erythroid cells: essential role of NF-Y [J].

Fujiwara, Tohru ;

Harigae, Hideo ;

Okitsu, Yoko ;

Takahashi, Shinichiro ;

Yokoyama, Hisayuki ;

Yamada, Minami F. ;

Ishizawa, Kenichi ;

Kameoka, Junichi ;

Kaku, Mitsuo ;

Sasaki, Takeshi .

BRITISH JOURNAL OF HAEMATOLOGY, 2006, 135 (04) :583-590

[8] VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo [J].

Harrington, EA ;

Bebbington, D ;

Moore, J ;

Rasmussen, RK ;

Ajose-Adeogun, AO ;

Nakayama, T ;

Graham, JA ;

Demur, C ;

Hercend, T ;

Diu-Hercend, A ;

Su, M ;

Golec, JMC ;

Miller, KM .

NATURE MEDICINE, 2004, 10 (03) :262-267

[9] The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [J].

Hussain, Shobbir ;

Benavente, Sandra Blanco ;

Nascimento, Elisabete ;

Dragoni, Ilaria ;

Kurowski, Agata ;

Gillich, Astrid ;

Humphreys, Peter ;

Frye, Michaela .

JOURNAL OF CELL BIOLOGY, 2009, 186 (01) :27-40

[10] Protein structure prediction on the Web: a case study using the Phyre server [J].

Kelley, Lawrence A. ;

Sternberg, Michael J. E. .

NATURE PROTOCOLS, 2009, 4 (03) :363-371

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