ENDOCRINE AND METABOLIC EFFECTS OF ADIPOSE TISSUE IN CHILDREN AND ADOLESCENTS

被引：15
作者：
Kotnik, Primoz [1 ,2 ]
Posovszky, Pamela Fischer [3 ]
Wabitsch, Martin [3 ]
机构：
[1] Univ Med Ctr Ljubljana, Univ Childrens Hosp, Dept Pediat Endocrinol Diabet & Metab Dis, Ljubljana 1000, Slovenia
[2] Univ Ljubljana, Fac Med, Ljubljana 1000, Slovenia
[3] Univ Ulm Klinikum, D-89070 Ulm, Germany
来源：
ZDRAVSTVENO VARSTVO | 2015年 / 54卷 / 02期
关键词：
adipose tissue; obesity; endocrinology; adipokine; metabolic syndrome; child; RETINOL-BINDING-PROTEIN; MORBIDLY OBESE SUBJECTS; PLASMA VISFATIN CONCENTRATIONS; IMPAIRED GLUCOSE-TOLERANCE; MESSENGER-RNA EXPRESSION; TYPE-2; DIABETES-MELLITUS; HUMAN SKELETAL-MUSCLE; INSULIN-RESISTANCE; SERUM RETINOL-BINDING-PROTEIN-4; WEIGHT-LOSS;
D O I：
10.1515/sjph-2015-0020
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Adipose tissue is implicated in many endocrine and metabolic processes. Leptin was among the first identified adipose-secreted factors, which act in an auto-, para- and endocrine manner. Since leptin, many other adipose tissue factors were determined, some primarily secreted from the adipocytes, some from other cells of the adipose tissue. So-called adipokines are not only involved in obesity and its complications, as are insulin resistance, type 2 diabetes and other components of the metabolic syndrome, but also in growth, reproduction, bone metabolism, immune response, cancer development and many other important biological processes. Research in the field of adipokines has revealed new insights into the physiological and pathophysiologal processes and opened new therapeutic possibilities. In the present article, a special emphasis is devoted to research in children and adolescents.
引用
收藏
页码：131 / 138
页数：8
相关论文
共 106 条
  • [1] Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children
    Aeberli, Isabelle
    Biebinger, Ralf
    Lehmann, Roger
    l'Allemand, Dagmar
    Spinas, Giatgen A.
    Zimmermann, Michael B.
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (11) : 4359 - 4365
  • [2] Novel resistin promoter polymorphisms: Association with serum resistin level in Japanese obese individuals
    Azuma, K
    Oguchi, S
    Matsubara, Y
    Mamizuka, T
    Murata, M
    Kikuchi, H
    Watanabe, K
    Katsukawa, F
    Yamazaki, H
    Shimada, A
    Saruta, T
    [J]. HORMONE AND METABOLIC RESEARCH, 2004, 36 (08) : 564 - 570
  • [3] Regulation of fasted blood glucose by resistin
    Banerjee, RR
    Rangwala, SM
    Shapiro, JS
    Rich, AS
    Rhoades, B
    Qi, Y
    Wang, J
    Rajala, MW
    Pocai, A
    Scherer, PE
    Steppan, CM
    Ahima, RS
    Obici, S
    Rossetti, L
    Lazar, MA
    [J]. SCIENCE, 2004, 303 (5661) : 1195 - 1198
  • [4] Overexpression of adiponectin targeted to adipose tissue in transgenic mice: Impaired adipocyte differentiation
    Bauche, Isabelle B.
    El Mkadem, Samira Ait
    Pottier, Anne-Marie
    Senou, Maximin
    Many, Marie-Christine
    Rezsohazy, Rene
    Penicaud, Luc
    Maeda, Norikazu
    Funahashi, Tohru
    Brichard, Sonia M.
    [J]. ENDOCRINOLOGY, 2007, 148 (04) : 1539 - 1549
  • [5] Adiponectin associates positively with nitrite levels in children and adolescents
    Belo, V. A.
    Souza-Costa, D. C.
    Lacchini, R.
    Sertorio, J. T.
    Lanna, C. M.
    Carmo, V. P.
    Tanus-Santos, J. E.
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2013, 37 (05) : 740 - 743
  • [6] Plasma visfatin concentrations and fat depot-specific mRNA expression in humans
    Berndt, J
    Klöting, N
    Kralisch, S
    Kovacs, P
    Fasshauer, M
    Schön, MR
    Stumvoll, M
    Blüher, M
    [J]. DIABETES, 2005, 54 (10) : 2911 - 2916
  • [7] Relation between retinol, retinol-binding protein 4, transthyretin and carotid intima media thickness
    Bobbert, Thomas
    Raila, Jens
    Schwarz, Franziska
    Mai, Knut
    Henze, Andrea
    Pfeiffer, Andreas F. H.
    Schweigert, Florian J.
    Spranger, Joachim
    [J]. ATHEROSCLEROSIS, 2010, 213 (02) : 549 - 551
  • [8] Assessment of adiponectin and leptin as biomarkers of positive metabolic outcomes after lifestyle intervention in overweight and obese children
    Cambuli, Valentina M.
    Musiu, M. Cristina
    Incani, Michela
    Paderi, Monica
    Serpe, Roberto
    Marras, Valeria
    Cossu, Efisio
    Cavallo, M. Gisella
    Mariotti, Stefano
    Loche, Sandro
    Baroni, Marco G.
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (08) : 3051 - 3057
  • [9] Hyperleptinemia: An early sign of juvenile obesity. Relations to body fat depots and insulin concentrations
    Caprio, S
    Tamborlane, WV
    Silver, D
    Robinson, C
    Leibel, R
    McCarthy, S
    Grozman, A
    Belous, A
    Maggs, D
    Sherwin, RS
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1996, 271 (03): : E626 - E630
  • [10] Retinol-binding protein 4 is associated with impaired glucose tolerance but not with whole body or hepatic insulin resistance in Mexican Americans
    Chavez, Alberto O.
    Coletta, Dawn K.
    Kamath, Subhash
    Cromack, Douglas T.
    Monroy, Adriana
    Folli, Franco
    DeFronzo, Ralph A.
    Tripathy, Devjit
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2009, 296 (04): : E758 - E764
12345678910