Potential targets for the development of new antifungal drugs

被引：48

作者：

Su, Hao ^{[1
]}

Han, Li ^{[1
]}

Huang, Xueshi ^{[1
]}

机构：

[1] Northeastern Univ, Inst Microbial Pharmaceut, Coll Life & Hlth Sci, Shenyang 110819, Liaoning, Peoples R China

来源：

JOURNAL OF ANTIBIOTICS | 2018年 / 71卷 / 12期

关键词：

CANDIDA-ALBICANS; SACCHAROMYCES-CEREVISIAE; HOMOSERINE TRANSACETYLASE; BIOSYNTHETIC-PATHWAY; SYNTHASE INHIBITORS; PHOSPHATE CARRIER; GENE-EXPRESSION; AGENTS; BROMODOMAIN; METABOLISM;

D O I：

10.1038/s41429-018-0100-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In recent years, incidences of invasive fungal infections have greatly increased, especially in immunosuppressed patients, but most today's antifungal drugs are not completely effective due to the development of drug resistance, as well as potential toxicity and adverse effects. Consequently, it is imperative to search for novel antifungal agents to combat fungal infections. This review will discuss the advances in the traditional antifungal therapy, and present an overview of novel strategies for the treatment of fungal infections. The papers presented here highlight new targets that could be exploited for development of new antifungal agents.

引用

页码：978 / 991

页数：14

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