Expression of co-inhibitory molecules B7-H4 and B7-H1 in Epstein-Barr virus positive diffuse large B-cell lymphoma and their roles in tumor invasion

被引：3
作者：
Jiang, Ying [1 ]
Lin, Jun [2 ]
Zhang, Jing [3 ,4 ]
Lu, Shasha [5 ]
Wang, Chun [1 ]
Tong, Yin [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Dept Hematol, 100 Haining Rd, Shanghai 200080, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Dept Pathol, 100 Haining Rd, Shanghai 200080, Peoples R China
[3] Fudan Univ, Shanghai Canc Ctr, Dept Integrated Therapy, 270 Dongan Rd, Shanghai 200032, Peoples R China
[4] Fudan Univ, Shanghai Med Coll, Dept Oncol, 138 Yi Xue Yuan Rd, Shanghai 200032, Peoples R China
[5] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Hematol, 160 Pujian Rd, Shanghai 200127, Peoples R China
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2019年 / 215卷 / 12期
关键词：
B7-H4; B7-H1; Epstein-Barr positive diffuse large B-cell lymphoma; EBV; DLBCL; CANCER PATIENTS; PD-L1; EBV; CARCINOMA; SURVIVAL; UPDATE; POOR;
D O I：
10.1016/j.prp.2019.152684
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
To investigate the relationship between immunoregulatory molecules B7-H4 and B7-H1 in Epstein-Barr positive diffuse large B-cell lymphoma (EMT+DLBCL). Immunohistochemistry was used to detect the expression of B7-H4 and B7-H1 in tumor tissues of 13 patients with EBV+DLBCL. The expression levels of B7-H4 and B7-H1 in four diffuse large B-cell lymphoma cell lines (SU-DHL-4, SU-DHL-10, SU-DHL-6, Pfeiffer) were analyzed by flow cytometry. Transwell invasion assays were conducted to observe the invasive ability of cell lines. B7-H4 and B7-H1 were expressed in 84.62% and 100% tumor specimens of EBV+DLBCL. The overexpression of B7-H4 and B7-H1 was found in 46.15% and 23.08% tumor samples of EBV+DLBCL. There was a medium negative correlation between the expression levels of B7-H4 and B7-H1 (r = -0.667, P = 0.013, spearman rank correlation). The expression levels of B7-H1 in four diffuse large B-cell lymphoma cell lines were positively correlated with their invasive ability, whereas the expression levels of B7-H4 were not. Here, we provide evidence for the negative relationship between B7-H4 and B7-H1 in EBV+DLBCL. The expression of B7-H1 in EBV+DLBCL appears to be the dominant factor which affects tumor aggressiveness. When B7-H1 expression weakens, the molecule B7-H4 may become the dominant factor of prognosis in patients with EBV+DLBCL.
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页数：7
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