A new isocoumarin from mangrove endophytic fungus (No. dz17) on the South China Sea coast

被引：24

作者：

Huang, Zhongjing ^{[1
]}

Shao, Changlun ^{[1
]}

Chen, Yiguang ^{[1
]}

She, Zhigang ^{[1
]}

Lin, Yongcheng ^{[1
]}

Zhou, Shining ^{[2
]}

机构：

[1] Zhongshan Univ, Coll Chem & Chem Engn, Guangzhou 510275, Peoples R China

[2] Zhongshan Univ, Coll Life Sci, Guangzhou 510275, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2007年 / 43卷 / 06期

基金：

中国国家自然科学基金;

关键词：

mangrove endophytic fungus; isocoumarin; metabolites;

D O I：

10.1007/s10600-007-0221-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new isocoumarin, 3,4-dihydro-6-methoxy-8-hydroxy-3,4,5-trimethylisocoumarin-7-carboxylic acid methyl ester (1), together with three known compounds, 3,4-dihydro-4,8-dihydroxy-3,5-dimethylisocoumarin (2), 3,4-dihydro-8-hydroxy-3-methylisocoumarin-5-carboxylic acid (3), and Entinclole SB (4) were isolated from the mangrove endophytic fungus (No. dz17). The structure of the compound 1 was elucidated by analysis of spectroscopic data. Primary bioassays showed that 1 exhibited weak cytotoxicity against Hep-2 and HepG2 cells.

引用

页码：655 / 658

页数：4

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