Isolevuglandins and cardiovascular disease

被引：14

作者：

Davies, Sean S. ^{[1
]}

May-Zhang, Linda S. ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Pharmacol, Div Clin Pharmacol, Nashville, TN 37235 USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2018年 / 139卷

基金：

美国国家卫生研究院;

关键词：

Lipid peroxidation; Reactive lipid species; Isolevuglandins; Cardiovascular disease; HDL; LOW-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-A-I; GAMMA-KETOALDEHYDES; PROTEIN ADDUCTS; ISOPROSTANE PATHWAY; PROSTAGLANDIN H-2; LEVUGLANDIN E(2); MYELOPEROXIDASE; CHOLESTEROL; OXIDATION;

D O I：

10.1016/j.prostaglandins.2018.10.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Isolevuglandins are 4-ketoaldehydes formed by peroxidation of arachidonic acid. Isolevuglandins react rapidly with primary amines including the lysyl residues of proteins to form irreversible covalent modifications. This review highlights evidence for the potential role of isolevuglandin modification in the disease processes, especially atherosclerosis, and some of the tools including small molecule dicarbonyl scavengers utilized to assess their contributions to disease.

引用

页码：29 / 35

页数：7

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