Substance Use and Adherence to HIV Preexposure Prophylaxis for Men Who Have Sex with Men

被引：45

作者：

Hoenigl, Martin ^{[1
,2
]}

Jain, Sonia ^{[2
]}

Moore, David ^{[2
]}

Collins, Deborah ^{[3
]}

Sun, Xiaoying ^{[2
]}

Anderson, Peter L. ^{[4
]}

Corado, Katya ^{[5
]}

Blumenthal, Jill S. ^{[2
]}

Daar, Eric S. ^{[5
]}

Milam, Joel ^{[6
]}

Dube, Michael P. ^{[6
]}

Morris, Sheldon ^{[2
]}

机构：

[1] Med Univ Graz, Graz, Austria

[2] Univ Calif San Diego, San Diego, CA 92103 USA

[3] Dept Hlth & Human Serv, Long Beach, CA USA

[4] Univ Anschutz Med Campus, Aurora, CO USA

[5] Harbor UCLA Med Ctr, Torrance, CA 90509 USA

[6] Univ Sothern Calif, Keck Sch Med, Los Angeles, CA 90033 USA

来源：

EMERGING INFECTIOUS DISEASES | 2018年 / 24卷 / 12期

基金：

美国国家卫生研究院;

关键词：

UNITED-STATES IMPLICATIONS; HIGH-RISK; ANTIRETROVIRAL PROPHYLAXIS; TRANSGENDER WOMEN; INJECT DRUGS; YOUNG MEN; INFECTION; PEOPLE; PREP; MSM;

D O I：

10.3201/eid2412.180400

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effectiveness of oral HIV preexposure prophylaxis (PrEP) strongly depends on maintaining adherence. We investigated the association between substance use and PrEP adherence, as well as incident sexually transmitted infections (STIs) in a high-risk cohort of 394 participants (391 men who have sex with men and 3 transgender women) who were enrolled in a PrEP demonstration project. We assessed baseline and ongoing substance use over a 48-week period for stimulants and nonstimulant substances and for each substance separately. We measured PrEP adherence by using dried blood spots to obtain levels of tenofovir diphos phate. No differences in these levels were found between substance users and nonsubstance users. Baseline stimulant use was strongly associated (odds ratio 3.4; p<0.001) with incident STIs during the study. Thus, PrEP adherence was not decreased by substance use. Because substance users had increased rates of STIs, indicating higher-risk behavior, they might be excellent candidates for PrEP.

引用

页码：2292 / 2302

页数：11

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